Chiral-specific boron-containing compounds and their use in the treatment of cancer or amyloidosis
A compound and composition technology, applied in the field of chiral specific boron-containing compounds, can solve problems such as instability
Active Publication Date: 2022-01-28
ARTIVILA BIOPHARMA
View PDF6 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
A major problem with such boronic acid compounds (active pharmaceutical ingredients, API) is that they are not very stable under usual environmental conditions such as drug Requires storage below ambient temperature and away from light, drug Formulated as an injection partly because of its instability, patients must go to the doctor's office or hospital to administer the drug
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0236] HL01-01 The product of Example 1, may be HL01-01-1, HL01-01-2, HL01-01-3, HL01-01-4, HL01-01-5 or mixtures thereof.
[0237]
Embodiment 2
[0238] HL01-02 embodiment of the product of Example 2, it may be HL01-02-1, HL-01-02-2, HL-01-02-3, HL-01-02-4 or mixtures thereof.
[0239]
Embodiment 15
[0240] The product of Example 15 HL01-17, may be HL01-17-1, HL01-17-2, HL01-17-3, HL-01-17-4, HL-1-17-5, or mixtures thereof.
[0241]
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
Useful chiral-specific boron-containing compounds, such as boronic esters, boraneamines, boranediamines, boraneamine thioesters, and boronic acid mono / dithiol esters, have been prepared, and compositions containing these compounds can be used in Anti-cancer or anti-amyloidosis disease.
Description
[0001] Cross-reference related application [0002] This application is based on US Provisional Patent June 19, 2015 filed equity No.62 / 181910, the entire contents of which are incorporated herein by reference. Technical field [0003] The present invention relates to boron-containing compound as a chiral specific anticancer or an anti-amyloid drug, such as boric acid, borate ester, amine boranes, borane-diamine, amine borane and borate thioesters mono / di thio esters, their composition, preparation and method of treatment. Background technique [0004] Some polypeptide containing boric acid as an inhibitor of proteasome plays a decisive role in the treatment of cancer, in addition to the drug commercially available (Bortezomib or [(lR) -3- methyl -1 - [[(2S) -1- phenyl-2-oxo-3 [(pyrazinylcarbonyl) amino] propyl] amino] butyl ] boronic acid) for the treatment of multiple myeloma, cancer and other types of amyloidosis diseases, there are many different structures in different ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/69A61K38/05
CPCC07K5/06191C07F5/022C07F5/025C07K5/06139C07K4/00A61K38/00
Inventor 韩国霞
Owner ARTIVILA BIOPHARMA