A kind of melon seed gold saponin spray and preparation method thereof

A technology of saponin and spray, which is applied in the directions of aerosol delivery, pharmaceutical formulations, and medical preparations with non-active ingredients, etc., to achieve the effects of fast onset, low dosage and convenient administration.

Active Publication Date: 2020-06-02
董宁霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on its use for cough and expectoration

Method used

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  • A kind of melon seed gold saponin spray and preparation method thereof
  • A kind of melon seed gold saponin spray and preparation method thereof
  • A kind of melon seed gold saponin spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The screening of embodiment 1 melon seed gold saponin aerosol absorption accelerator

[0018] Accurately weigh an appropriate amount of melon saponin, sodium lauryl sulfate, sodium ethylenediaminetetraacetate, HP-β-cyclodextrin, povidone and laurocaprazine, dissolve with appropriate amount of distilled water, and respectively make 5 % of sodium lauryl sulfate, sodium edetate, HP-β-cyclodextrin, povidone or lauroazepine solution, as the test sample, and no absorption enhancer of guanoside aqueous solution as a blank control. The concentration of melon seeds gold saponin is 100mg·mL -1 .

[0019] The Franz diffusion cell was selected as the experimental device, the upper part of the Franz diffusion cell was the dosing cell, and the lower part was the receiving cell. The experimental conditions are as follows: receiving solution: physiological saline; receiving solution volume: 8.0mL; stirring speed: 250rpm; circulating water bath temperature: 37.5°C; sampling volume: 0...

Embodiment 2

[0033] The preparation of embodiment 2 melon seed gold saponin spray

[0034] Melon seed gold saponin spray Ⅰ: Accurately weigh 10g of melon seed gold saponin, 1g of chlorobutanol and 5g of povidone, add 50mL of distilled water, place on a water bath shaker and heat to 40°C to dissolve completely, and make up distilled water to 100mL, adjust the pH to 7.5 with meglumine, fill it into a spray bottle, and get the concentration of melon saponin 100mg·mL -1 spray.

[0035] Guazi Jinsaponin Spray II: Accurately weigh 12g of Guazijinsaponin, 1.2g of chlorobutanol and 6g of povidone, add 50mL of distilled water, place on a water bath shaker and heat to 40°C to dissolve completely, and make up distilled water to 100mL, adjust the pH to 7.5 with meglumine, and fill it into a spray bottle to obtain a concentration of 120mg·mL -1 spray.

[0036] Guazi Jinsaponin Spray III: Accurately weigh 16g of Guazijinsaponin, 1.6g of chlorobutanol and 8g of povidone, add 50mL of distilled water, p...

Embodiment 3

[0038] Example 3 Study on Stability of Melon Seed Golden Saponin Spray

[0039] (1) Influencing factor test

[0040] Get the Guazi Jinsaponin I spray I in Example 2 and fill it in a 5mL ampoule, put it under the conditions of high temperature (40°C), light (4500±500Lx), and low temperature (-18°C), and place it on the 5th and 10th day respectively. The samples were taken every day, and each index of the stability test was tested, and the results are shown in Table 3.

[0041] Table 3 Guazi Jinsaponin Affecting Factor Test Results

[0042]

[0043]

[0044]According to the above results, it can be known that the melon seed gold saponin spray of the present invention can exist stably after being placed under high temperature and low temperature conditions for 10 days, but the content decreases after being placed under light conditions for 10 days, and the related substances increase. light device and store away from light.

[0045] (2) Accelerated test

[0046] Get the...

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Abstract

The invention belongs to the technical field of pharmaceutic preparation and particularly relates to a polygalasaponin aerosol and a preparation method thereof. The polygalasaponin aerosol is preparedfrom polygalasaponin, a pH modifier, a preservative, a sorbefacient and distilled water, wherein the pH is 7.0-7.8. The polygalasaponin aerosol is a novel product. A formula is obtained after specific experiments are carried out, and screening of the sorbefacient, the pH modifier and the preservative is based on a great number of tests. The polygalasaponin aerosol is reasonable in formula, a stability experiment and a cilium toxicity experiment both meet requirements, and moreover, polygalasaponin is used for preparing medicine combinations with efficacy of relieving a cough and eliminating phlegm for the first time. An effect experiment proves that excellent effects of relieving a cough and eliminating phlegm are achieved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a guanoside saponin spray and a preparation method thereof. Background technique [0002] According to the statistics of the national health department, nearly 300 million people in my country are infected with respiratory diseases every year, of which more than 50 million people suffer from cough. At the same time, the more developed the economy, the higher the incidence of respiratory diseases. Therefore, cough-relieving products have a huge consumer group and a broad market prospect. After decades of market cultivation, the cough medicine market has grown into a relatively mature market. There are no less than 40 kinds of cough medicine products sold in major pharmacies, with prices ranging from high to low. According to the estimates of relevant departments, a total of 194.05 million urban and rural residents in my country have cough symptoms...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K47/32A61K47/10A61K47/18A61K31/704A61P11/14A61P11/10
CPCA61K9/0043A61K9/12A61K31/704A61K47/10A61K47/18A61K47/32
Inventor 董宁霞成植温吕文文高行
Owner 董宁霞
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