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Preparation method of almagate

A preparation process, aluminum-magnesium-added technology, applied in the direction of active ingredients of aluminum/calcium/magnesium, medical preparations containing active ingredients, aluminum compounds, etc., can solve the problems of difficult gas control, high risk, and generation of impurities, and achieve The raw materials are cheap and easy to obtain, the operation is simple, and the quality is stable and controllable

Inactive Publication Date: 2018-06-15
上海裕英生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] 1) The gas is not easy to control and is relatively dangerous;
[0015] 2) The introduction of ga

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Aluminum hydroxide (7.8g, 0.1mol), magnesium hydroxide (17.5g, 0.3mol), sodium bicarbonate (12.6g, 0.15mol) and purified water (500ml) were added in the reaction flask, and after stirring vigorously for 15 minutes, Heat to 95-100° C., react for 6-8 hours, cool to room temperature, then filter, wash with pure water, and dry to obtain 31.18 g of the product (99% yield). Calculation: Al 2 Mg 6 (OH) 14 (CO 3 ) 2 4H 2 O: Al 2 o 3 : 16.185%, MgO: 38.39%, CO 2 : 13.97%. Sample measured value: Al 2 Mg 6 (OH) 14 (CO 3 ) 2 4H 2 O: Al 2 o 3 : 16.191%, MgO: 38.40%, CO 2 : 13.95%.

Embodiment 2

[0030] Aluminum hydroxide (7.8g, 0.1mol), magnesium hydroxide (17.5g, 0.3mol), potassium bicarbonate (15.02g, 0.15mol) and purified water (500ml) were added in the reaction flask, and after stirring vigorously for 15 minutes, Heating to 95-100° C., reacting for 6-8 hours, cooling to room temperature, then filtering, washing with pure water, and drying to obtain 31.03 g of the product (98.5% yield). Calculation: Al 2 Mg 6 (OH) 14 (CO 3 ) 2 4H 2 O: Al 2 o 3 : 16.185%, MgO: 38.39%, CO 2 : 13.97%. Sample measured value: Al 2 Mg 6 (OH) 14 (CO 3 ) 2 4H 2 O: Al 2 o 3 : 16.190%, MgO: 38.42%, CO 2 : 13.94%.

Embodiment 3

[0032] Aluminum oxide (10.2g, 0.1mol), magnesium oxide (12.9g, 0.3mol), sodium bicarbonate (12.6g, 0.15mol) and purified water (500ml) were added to the reaction flask, stirred vigorously for 15 minutes, and heated to 95 After reacting for 6-8 hours at -100°C, cool to room temperature, then filter, wash with pure water, and dry to obtain 31.06 g of the product (98.6% yield). Calculation: Al 2 Mg 6 (OH) 14 (CO 3 ) 2 4H 2 O: Al 2 o 3 : 16.185%, MgO: 38.39%, CO 2 : 13.97%. Sample measured value: Al 2 Mg 6 (OH) 14 (CO 3 ) 2 4H 2 O: Al 2 o 3 : 16.20%, MgO: 38.42%, CO 2 : 13.99%.

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Abstract

The invention relates to a preparation method of almagate. The preparation method comprises dissolving a bicarbonate substance, alkaline aluminum and alkaline magnesium in purified water to form a mixed solution, stirring the solution for a reaction, and carrying out cooling, filtration, washing and drying. The preparation method is easy to operate and utilizes cheap and easily available raw materials. The prepared almagate has stable and controllable quality, satisfies the requirements in pharmacopoeia and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of aluminum-magnesium preparation, in particular to a preparation process of aluminum-magnesium. Background technique [0002] Aluminum hydroxide gel and its mixture with magnesium hydroxide are currently widely used in pharmaceutical formulations, and are used as antacids in the treatment of gastrointestinal diseases related to hyperacidity. A disadvantage of these formulations is that the substance produces over-alkalization resulting in a reflexive gastric acid condition; furthermore, the importance of bile acid reflux in higher organ disorders of the gastrointestinal tract is well accepted according to modern medical opinion. The above-mentioned formulations cannot control bile acids and limit their effectiveness; moreover, they also cause aging and structural changes of the aluminum hydroxide gel, thereby reducing the acid neutralization performance. The new compound I does not have these disadvantages, and we c...

Claims

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Application Information

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IPC IPC(8): A61K33/08A61K33/00A61P1/04C01F7/00
CPCA61K33/00A61K33/08C01F7/785A61K2300/00
Inventor 沈国兵
Owner 上海裕英生物医药科技有限公司
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