Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

PH-sensitive konjac glucomannan-lipidosome compound nano drug carrier for injection, preparation and application thereof

A technology of konjac glucomannan and nano-drug carrier, which is applied in liposome delivery, drug combination, drug delivery, etc., and can solve the problems that it is difficult to load drugs with different hydrophilicity and hydrophobicity at the same time, and it is impossible to realize synergistic drug delivery.

Inactive Publication Date: 2018-06-22
HUBEI UNIV OF TECH
View PDF1 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the micelles can only be loaded with hydrophobic molecules, and it is difficult to load drugs with different hydrophilicity and hydrophobicity at the same time, and it is impossible to achieve synergistic drug delivery in practical applications.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • PH-sensitive konjac glucomannan-lipidosome compound nano drug carrier for injection, preparation and application thereof
  • PH-sensitive konjac glucomannan-lipidosome compound nano drug carrier for injection, preparation and application thereof
  • PH-sensitive konjac glucomannan-lipidosome compound nano drug carrier for injection, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Weigh 0.5 g of KGM and disperse it in 250 mL of deionized water, mechanically stir and swell at room temperature for 24 hours to prepare KGM1 dispersion; weigh 0.2 g of sodium periodate, dissolve in 10 mL of deionized water, and add dropwise to the KGM dispersion. The reaction was stirred at room temperature and dark for 48 hours, concentrated under reduced pressure at 40°C, filtered, and finally transferred to a dialysis bag with a molecular weight cut-off of 3500g / mol (3500MW) to remove salts and small molecular products and lyophilized for 48h to obtain white DAK1 powder.

Embodiment 2

[0083] Weigh 0.5 g of KGM and disperse it in 250 mL of deionized water, mechanically stir and swell at room temperature for 12 hours to prepare KGM2 dispersion; weigh 0.3 g of sodium periodate, dissolve in 15 mL of deionized water, and add dropwise to the KGM dispersion. The reaction was stirred at room temperature and dark for 24 hours, concentrated under reduced pressure at 50°C, filtered, and finally transferred to a 3500MW dialysis bag to remove salts and small molecular products, and freeze-dried for 48 hours to obtain white DAK2 powder.

Embodiment 3

[0085] Weigh 0.5 g of KGM and disperse it in 250 mL of deionized water, mechanically stir and swell at room temperature for 12 hours to prepare KGM3 dispersion; weigh 0.4 g of sodium periodate, dissolve in 20 mL of deionized water, and add dropwise to the KGM dispersion. The reaction was stirred at room temperature and dark for 24 hours, concentrated under reduced pressure at 55°C, filtered, and finally transferred to a 3500MW dialysis bag for dialysis to remove salts and small molecular products, and freeze-dried for 48 hours to obtain white DAK3 powder.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a pH-sensitive konjac glucomannan-lipidosome compound nano drug carrier for injection, preparation and application thereof, and belongs to the technical field of biological materials and slow release. The pH-sensitive konjac glucomannan-lipidosome compound nano drug carrier is characterized in that hydrophobic modified konjac glucomannan and lipidosome are compounded and assembled by an ethanol injection method and a thin-film hydration method and the like, the obtained nano drug carrier has higher encapsulation efficiency for both hydrophilic and hydrophobic drugs, andcan be loaded with different hydrophilic and hydrophobic drugs to realize synergistic transfer. The nano drug carrier can be enriched to tumor tissues by EPR (Enhanced Permeability and Retention) effect, due to the pH sensitivity, the drugs can be selectively released in the tumor tissues, and in normal tissues and blood, the physical and chemical stability of the entrapped drugs are obviously improved. The drug-loaded KGM-LIPO compound nano drug carrier is stable in structure, simple in preparation method, good in biocompatibility and low in cytotoxicity, has an obvious effect in killing tumor cells, and can be used in the fields of drug control release and synergistic treatment and the like.

Description

Technical field [0001] The invention relates to the technical field of biological materials and controlled release, in particular to a pH-sensitive konjac glucomannan-liposome composite nano-medicine carrier for injection equipment and its preparation and application. Background technique [0002] At present, the global incidence and mortality of cancer are increasing, which has become the greatest threat to human health. Chemotherapy is currently the most widely used cancer treatment method, but there are also many problems, such as poor water solubility of the drug, poor selectivity in the body after administration, multi-drug resistance, short circulation time, low bioavailability, etc. Patent Document 1: Expertopinion on drug delivery, 2012, 9:687-700). To solve these problems, micro- and nano-carriers have been extensively studied. Liposomes have the advantages of good biocompatibility, amphiphilic properties, and can simultaneously encapsulate hydrophilic and hydrophobic ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/127A61K47/36A61K45/00A61P35/00C08B37/02
CPCA61K9/0019A61K9/1273A61K9/1277A61K45/00C08B37/009
Inventor 匡映栾金玲姜发堂姚晓琳乔冬玲
Owner HUBEI UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com