Unlock instant, AI-driven research and patent intelligence for your innovation.
6-Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A compound, CF3 technology, applied in the field of cyclin-dependent kinase 4 and 6, can solve the problem of difficulty in identification and inhibition
Active Publication Date: 2020-10-23
SHENGKE PHARMA JIANGSU LTD
View PDF1 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Review articles on small molecule inhibitors of cyclin-dependent kinases have noted the difficulty of identifying compounds that inhibit specific CDK proteins but not other enzymes
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0309] Put 2a (5g, 17.46mmol), hydroxylaminehydrochloride (2.67g, 38.41mmol) and sodiumbicarbonate (3.23g, 38.41mmol) in a reaction flask, add tert-butanol (60mL), stir and heat to 70°C React overnight. After reaching room temperature, the reaction solution was diluted with methanol (80 mL) and filtered, and the crude product obtained after the filtrate was concentrated was filtered again, and washed with a solvent (methyl tert-butyl ether / petroleumether=3:1, about 15 mL) to obtain a yellow solid namely 3a (5.2 g, 93.4%).
[0310] 1 H NMR (400MHz, DMSO-d 6 ,ppm):δ9.70(s,1H),8.99(s,1H),8.19(s,1H),5.94(br,2H),5.94–5.82(m,1H),2.59(s,3H), 2.31–2.17(m,2H),2.07–1.93(m,2H),1.90–1.77(m,2H),1.71–1.58(m,2H).
[0327] Put 5a (200mg, 0.556mmol) and 6b (170.4mg, 0.612mmol) in a dry 15mL branched reaction tube, seal with a rubber stopper and replace with argon for 3 times, add toluene (5mL), stir and heat under the protection of an argonballoon React at 100°C for 6 hours. After cooling down to room temperature, a small amount of ethyl acetate was added, and stirring was continued for about 2 hours. The precipitated solid was filtered and washed with ethyl acetate to obtain a yellow solid which was V-2a (102 mg, 32%).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The present invention provides 6-substituted pyrido[2,3-d]pyrimidine compounds of general formula (I), which can be used to treat cell proliferation disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 and 6 (CDK4 / 6).
Description
[0001] field of invention [0002] The present invention provides a 6-substituted pyrido[2,3-d]pyrimidine compound as a cyclin-dependent kinase inhibitor, especially cyclin-dependent kinase 4 and 6. The compounds of the present invention are useful in the treatment of cancer, inflammation, and also in the treatment of neurodegenerative diseases such as Parkinson's disease. Background technique [0003] Cancer is the second leading cause of death in the world. According to the "Global Cancer Report 2014" released by the World Health Organization, cancer patients and deaths worldwide are increasing disturbingly. Nearly half of the new cancer cases occur in Asia, most of which are in China. The report also predicts that global cancer cases will show a rapid growth trend, from 14 million in 2012 to 19 million in 2025, and will reach 24 million by 2035, of which China will account for 21.9% of the global total. According to institutional data, in the past 30 years, my country's c...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
![6-Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/d0569b61-5439-44a5-8511-48f94d09ad76/BDA0001553119070000041.png)
![6-Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/d0569b61-5439-44a5-8511-48f94d09ad76/BDA0001553119070000181.png)
![6-Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors](https://images-eureka.patsnap.com/patent_img/d0569b61-5439-44a5-8511-48f94d09ad76/BDA0001553119070000201.png)
Login to View More 
Login to View More