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Methods for treating autism spectrum disorder and associated symptoms

A technology for autism and symptoms, applied in the direction of bacterial medical raw materials, digestive system, pharmaceutical formulations, etc., can solve the problem of not reducing or eliminating the symptoms of autism spectrum disorder

Inactive Publication Date: 2018-07-03
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] To date, there are no FDA-approved methods for reducing or eliminating symptoms of autism spectrum disorder

Method used

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  • Methods for treating autism spectrum disorder and associated symptoms
  • Methods for treating autism spectrum disorder and associated symptoms
  • Methods for treating autism spectrum disorder and associated symptoms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Embodiment 1: A method of treating an autism spectrum disorder in a human subject comprising:

[0127] (a) administering an antibiotic to a human subject;

[0128] (b) the subject sends the human subject to a bowel cleanse; and

[0129] (c) administering the purified fecal microbiota to a human subject; wherein autism spectrum disorder is treated in the human subject.

Embodiment 2

[0130] Embodiment 2. The method of Embodiment 1, wherein the antibiotic is a non-absorbable antibiotic administered orally to a human subject.

Embodiment 3

[0131] Embodiment 3: The method of Embodiment 1 or 2, wherein the antibiotic is vancomycin.

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Abstract

The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with orwithout ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment describedhere.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Nos. 62 / 165,556, filed May 22, 2015, the entire contents of which are hereby incorporated by reference. Background technique [0003] The present disclosure relates to methods of treating autism spectrum disorder (ASD). Autism spectrum disorder (ASD) is a complex neurodevelopmental state characterized by widespread abnormalities in social interactions and interactions, as well as restricted interests and repetitive behaviors. ASD typically presents in the first three years of life with characteristic symptoms or behavioral features. The diagnosis of ASD now includes several conditions that were previously diagnosed separately: autism disorder, pervasive developmental disorder not otherwise specified (PDD-NOS), and Asperger's syndrome. Diagnostic criteria for autism spectrum disorder, as set forth in the American Psychiatric Association's Diagnostic a...

Claims

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Application Information

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IPC IPC(8): A61K35/38A61K35/74A61P25/00A61K38/08
CPCA61K35/74A61K35/747A61K45/06A61P1/00A61P1/04A61P1/06A61P1/10A61P1/12A61P1/14A61P25/00A61P25/18A61P43/00A61K9/19A61K2300/00A61K38/14A61K2035/128A61K38/08A61K35/741
Inventor J·亚当斯R·克拉马尼克-布朗D-W·康M·J·萨多斯基A·寇拉斯T·J·鲍罗迪
Owner THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA
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