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Method for extracting alkaloid in sonchus brachyotus

An extraction method and technology of chicory, applied in the directions of pharmaceutical formulations, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problems of unacceptable cost to users, increased difficulty in manufacturing ultrasonic equipment, and difficult to achieve, etc., Achieve the effects of low extraction process cost, significant comprehensive economic benefits and high extraction efficiency

Active Publication Date: 2018-07-06
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, restricted by the ultrasonic attenuation factor, the effective area of ​​ultrasonic action is a ring, and an ultrasonic blank area will be formed on the peripheral wall of the tank; The output power makes it more difficult to manufacture ultrasonic equipment, and at the same time, the cost cannot be accepted by users

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  • Method for extracting alkaloid in sonchus brachyotus
  • Method for extracting alkaloid in sonchus brachyotus
  • Method for extracting alkaloid in sonchus brachyotus

Examples

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Embodiment 1

[0021] Test drugs: aconitine reference substance; long-split chicory; sodium hydroxide, hydrochloric acid, absolute ethanol, bromothymol blue indicator solution, potassium hydrogen phthalate, chloroform, anhydrous sodium sulfate, ammonia water, formazan The base reds were all analytically pure.

[0022] 1. Draw aconitine standard curve

[0023] Accurately weigh 12.0mg of aconitine standard product and place it in a 50mL volumetric flask, add a few drops of 1mol / L hydrochloric acid solution, wait for the aconitine to dissolve, add an equivalent amount of 1mol / L sodium hydroxide solution, and dilute with distilled water to scale, and shake well to obtain aconitine standard solution with a concentration of 0.24mg / mL.

[0024] Accurately measure 0, 0.35, 0.40, 0.50, 0.80, 1.00 mL of aconitine standard solution, place them in a separatory funnel respectively, add 3.00, 2.65, 2.60, 2.50, 2.20, 2.00 mL of distilled water, add bromothyme Phenol blue indicator solution 2.0mL, potassi...

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Abstract

The invention relates to the field of extraction of effective components of traditional-Chinese-medicine plants and particularly relates to a method for extracting alkaloid in sonchus brachyotus. Themethod comprises the following steps of: adding ethyl alcohol into sonchus brachyotus powder, and carrying out ultrasonic treatment for 30 minutes at the ultrasonic power of 700w under the condition that the temperature is 55 DEG C and the pH is 5. The solid-liquid ratio of the sonchus brachyotus to ethyl alcohol is 1:30g / mL, and the concentration of ethyl alcohol is 75%. The method has the beneficial effects that the extracting efficiency is high, and due to unique physical property of the ultrasonic wave, the wall breaking or deformation of cell tissues of the plants can be promoted, so thatthe traditional-Chinese-medicine effective components can be extracted more fully, and the extraction rate can be obviously increased by 50-500% compared with that of the traditional process.

Description

technical field [0001] The invention relates to the field of extraction of effective components of traditional Chinese medicinal plants, in particular to a method for extracting alkaloids from chicory longifolia. Background technique [0002] Sonchus brachyotus DC. is an annual herbaceous plant belonging to the family Asteraceae. It is widely distributed and rich in resources. Pharmacological studies have shown that endive has anti-tumor, anti-bacterial, anti-inflammatory, anti-arrhythmic, antihypertensive and cholesterol-lowering effects, liver protection, and free radical scavenging. [0003] Using modern separation technology to extract and separate the effective active ingredients in natural Chinese herbal medicines, and then effectively use the extracted active ingredients, this is also one of the hotspots in the fields of medicine, biology, food and chemical industry. Ultrasonic-assisted extraction technology mainly uses the high acceleration, strong cavitation effect...

Claims

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Application Information

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IPC IPC(8): A61K36/28
CPCA61K36/28A61K2236/333
Inventor 李秀梅杨培龙潘方方刘婧闻治国
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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