Pig foot-and-mouth disease virus O type and A type Fc polypeptide bivalent vaccine, as well as preparation method and application thereof

Abstract

The invention discloses a pig foot-and-mouth disease virus O type and A type Fc polypeptide bivalent vaccine, as well as a preparation method and application thereof. The bivalent vaccine is preparedfrom effective components of pig foot-and-mouth disease virus A type Fc polypeptide and pig foot-and-mouth disease virus O type Fc polypeptide, wherein an amino acid sequence of the pig foot-and-mouthdisease virus A type Fc polypeptide is as shown in SEQ ID NO.3; an amino acid sequence of the pig foot-and-mouth disease virus O type Fc polypeptide is as shown in SEQ ID NO.5. Experimental results show that the bivalent vaccine can induce a body to produce a high-level neutralizing antibody against O type and A type foot-and-mouth disease viruses after being subjected to booster immunization, can protect immunized pigs against the attack of the O type and A type foot-and-mouth disease viruses, and realizes 5 / 5 protection (i.e. the protection rate is 100 percent). The pig foot-and-mouth disease virus O type and A type Fc polypeptide bivalent vaccine, as well as the preparation method and the application thereof provided by the invention provide a technical support and vaccine storage forguaranteeing healthy sustainable development of animal husbandry in China and realizing a mid-and-long-term prevention and control aim of foot-and-mouth disease countries.

Description

technical field [0001] The invention relates to a porcine foot-and-mouth disease vaccine and its preparation method and application, in particular to a porcine foot-and-mouth disease virus O-type and A-type Fc polypeptide bivalent vaccine and its preparation method and application. The invention belongs to the technical field of medicine. Background technique [0002] As a major animal disease, foot-and-mouth disease not only seriously threatens the healthy development of animal husbandry, but also involves the safety of animal-derived food and its foreign trade export. Once an epidemic occurs, the losses will be heavy and the impact will be severe. The World Organization for Animal Health (OIE) lists it as an infectious disease that must be notified, and my country lists it as a first-class animal infectious disease. In order to purify and eliminate foot-and-mouth disease, my country has formulated the "National Medium- and Long-Term Animal Disease Prevention and Control P...

AI Technical Summary

Problems solved by technology

Therefore, the development of inactivated foot-and-mouth disease vaccines by classical methods can no longer meet the requirements of foot-and-mouth disease prevention and control under the new situation.

Images