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Nanocellulose-based medical implants

A technology of implants and microbial cellulose, applied in the field of medical implants based on nanocellulose

Active Publication Date: 2021-10-01
耶拿大学综合医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, not every patient has a suitable vein, and to obtain the necessary vein segment, additional surgical intervention is required

Method used

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  • Nanocellulose-based medical implants
  • Nanocellulose-based medical implants
  • Nanocellulose-based medical implants

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0137] B) Example 1: Preparation of an implant

[0138] a) Preparation of BNC tube:

[0139] as in WO 2013 / 113675 A1 figure 1 The apparatus and reactor shown and described were used to prepare BNC tubes. To prepare the product, a plurality of stick molds are arranged in a jig and embedded in the moving parts of the device. The reactor is then closed and sterilized. After sterilizing the entire reactor, the reservoir of the reactor is filled under aseptic conditions with a mixture of cellulose-producing microorganisms and separately sterilized culture broth.

[0140] Then, start the unit's engine and perform the following steps:

[0141] - immersing the mold in the mixture of cellulose-producing microorganisms and culture fluid in the reservoir, thereby contacting the surface of the mold,

[0142] - removing the mold from the reservoir, thereby interrupting the contact between the mold and the mixture, wherein a liquid film comprising the liquid medium and the microorganis...

example 2

[0157] C) Example 2: Insertion of an implant in an animal to regenerate a bile duct.

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Abstract

A medical implant (100), comprising: - a microbial cellulose tube (1) comprising a wall (2) having an inner surface (3) and an outer surface (4), wherein the The wall comprises a plurality of layers (5, 6, 7) made of microbial cellulose, wherein the layers are coaxial or approximately coaxial with the longitudinal axis (L) of the tube, - a bracket (9), which arranges In a microbial cellulose tube (1), wherein the outer surface (10) of the scaffold is in contact with the inner surface (3) of the microbial cellulose tube (1); and a method for manufacturing such an implant. The implant may be covered by newly generated biliary epithelium, thereby forming a new bile duct from somatic cells. The implant may be removed after formation of the new bile duct is complete. Therefore, the implant is suitable as a temporary implant. The implant may be used in surgical procedures such as gallbladder surgery, bile duct surgery and / or liver surgery such as cholecystectomy, surgery for hepatobiliary malignancies or liver transplantation. The implant can be used in particular for the repair or regeneration of bile ducts. A further field of application is the use as an esophageal or urethral implant.

Description

technical field [0001] The invention relates to a medical implant, in particular for repairing bile ducts, and a method for manufacturing such an implant. Background technique [0002] Reconstructing the bile duct is often a critical issue in hepatobiliary surgery because the absence of bile duct material often forces the surgeon to perform high-risk procedures or procedures such as biliary-enteric anastomosis. Such material loss or damage may occur when the gallbladder is removed with incidental damage to the common bile duct, or when the damage is caused by ischemia, eg, after liver transplantation or tumor resection. [0003] Reconstruction of such injuries is complex. In most cases, a so-called "bilioenterostomy," which is a connection between the common bile duct and part of the gastrointestinal tract, must be performed. During this procedure, a loop of intestine connects to the common bile duct. The fundamental problem with this approach is to bypass the sphincter m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/00A61L31/10A61L31/14
CPCA61L31/005A61L31/10A61L31/146A61L2400/12A61L2420/08C08L1/00A61F2/04A61F2002/044A61F2002/041A61F2240/004A61F2240/005A61L2430/22C08L1/02
Inventor F·劳赫富斯U·塞特马赫尔D·克莱姆W·弗里德T·里希特K·佩措尔德-韦尔克C·鲁厄
Owner 耶拿大学综合医院
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