Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof

A technology for Parkinson's disease and a composition is applied in the field of traditional Chinese medicine compositions for treating Parkinson's disease and the field of preparation thereof, which can solve the problems of large side effects, short levodopa honeymoon period, poor curative effect on non-motor symptoms, etc., and achieves improvement in exercise. Symptoms, improvement of non-motor symptoms, improvement of fatigue

Active Publication Date: 2018-07-20
DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dopaserazide Tablets, Carlevodopa Controlled Release Tablets, Pramipexole Hydrochloride Tablets, Pirabedil Sustained Release Tablets, Entacapone Tablets, Selegiline Hydrochloride Tablets and other Parkinson’s disease drugs are commonly used in the treatment of Parkinson’s disease Clinically, the current drug treatment has unsatisfactory curative effect, motor fluctuation, short honeymoon period of levodopa, and large side effects. Surgical treatment has certain limitations. The current method has poor curative effect on non-motor symptoms. Traditional Chinese medicine treatment has its own advantages. Relieve motor and non-motor symptoms from multiple levels

Method used

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  • Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof
  • Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof
  • Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A traditional Chinese medicine composition for treating Parkinson's disease, comprising in parts by weight: 12 parts of medlar, 15 parts of schisandra, 12 parts of chrysanthemum, 20 parts of cistanche, 12 parts of Gastrodia elata, and 15 parts of cornus , 15 parts of sealwort, 15 parts of Ganoderma lucidum, 10 parts of sliced ​​turmeric.

[0035] Take an appropriate amount of the above-mentioned traditional Chinese medicine composition, add water to decoct according to a conventional method, and concentrate it into a decoction, each mL of decoction is equivalent to containing 4g of crude drug.

Embodiment 2

[0037] Take an appropriate amount of the traditional Chinese medicine composition of Example 1, add water to decoct according to the conventional method, concentrate and add appropriate amount of pharmaceutical excipients to make granules, and each 1g of granules is equivalent to containing 6g of crude drug.

Embodiment 3

[0039] A traditional Chinese medicine composition for treating Parkinson's disease, comprising in parts by weight: 5 parts of medlar, 5 parts of schisandra, 5 parts of chrysanthemum, 5 parts of cistanche, 5-20 parts of Gastrodia elata, cornus 10 parts, 10 parts of sealwort, 10 parts of ganoderma lucidum, 10 parts of sliced ​​turmeric.

[0040] Weigh each component of the composition according to the above ratio, then dry, pulverize into fine powder, sieve, and mix uniformly to obtain a pharmaceutical composition; Instant pill.

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Abstract

The invention relates to a traditional Chinese medicine composition for treating Parkinson's disease and a preparation method and application thereof. The traditional Chinese medicine composition fortreating Parkinson's disease is prepared from, by weight, 5-30 parts of barbary wolfberry fruits, 5-30 parts of Chinese magnoliavine fruits, 5-30 parts of flastem milkvetch seeds, 5-30 parts of papermulberry fruits, 10-30 parts of Cistanche deserticola, 5-20 parts of rhizoma gastrodiae, 10-30 parts of fructus corni, 10-20 parts of rhizoma polygonati, 10-20 parts of glossy ganoderma and 10-20 parts of rhizoma wenyujin concisum. According to the traditional Chinese medicine composition, based on cognition and a treatment principle for pathogenesis of Parkinson's disease of traditional Chinese medicine, with reference of modern pharmacological research, according to a composition principle of tonifying the kidney and heart, activating blood and relieving dizziness, the composition is prepared. The medicine composition is a pure traditional Chinese medicine preparation, the motor symptoms and non-motor symptoms of patients with Parkinson's disease can be improved, and particularly for limitation of western medicine for treating Parkinson's disease on the non-motor symptoms, the medicine composition can remarkably improve the non-motor symptoms of fatigue, constipation and the like ofthe patients, has no toxic medicine and is suitable for long-time application.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating Parkinson's disease, a preparation method and application thereof. Background technique [0002] Parkinson's disease (PD) is a common neurodegenerative disease. The prevalence rate of people over 65 years old in my country is 1700 / 100,000, and it increases with age. Bring a heavy burden. At present, Parkinson's disease mainly focuses on drug treatment and surgical treatment. Surgical treatment has certain indications, and the cost is relatively high. Drug treatment is the main treatment method for Parkinson's disease. Dopaserazide tablets, card Parkinson's disease drugs such as levodopa controlled-release tablets, pramipexole hydrochloride tablets, piribedil sustained-release tablets, entacapone tablets, and selegiline hydrochloride tablets are commonly used in clinical practice. Unsatisfactory...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/16
CPCA61K36/074A61K36/40A61K36/481A61K36/57A61K36/60A61K36/64A61K36/79A61K36/815A61K36/8969A61K36/8988A61K36/9066A61K2300/00
Inventor 陈志刚陈路
Owner DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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