Probiotic composition, preparation and use for treating Parkinson's disease REM sleep behavior disorder

A probiotic preparation, a technology for Parkinson's disease, which can be used in drug combinations, medical preparations containing active ingredients, bacteria, etc., can solve the problems of increasing family care pressure, even hallucinations, and aggravating RBD, and achieve good clinical application prospects and Market prospect, reduced dosage, good protective effect

Active Publication Date: 2021-11-23
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, some patients may experience RBD aggravation, or even hallucinations, etc. Sleep disorders directly affect the clinical progress of their disease, causing a vicious circle and greatly increasing the care pressure on family members

Method used

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  • Probiotic composition, preparation and use for treating Parkinson's disease REM sleep behavior disorder
  • Probiotic composition, preparation and use for treating Parkinson's disease REM sleep behavior disorder
  • Probiotic composition, preparation and use for treating Parkinson's disease REM sleep behavior disorder

Examples

Experimental program
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preparation example Construction

[0054] The preparation method of the frozen powder is a conventional technique, and it can be referred to known techniques such as CN110367543A, CN110720638A, CN102356912B.

[0055] The probiotic composition, preparation method and colony standard of the present invention are in line with the "China Pharmacopoeia" 2010 Edition and China Biological Product Procedure 2000 Edition.

[0056] The CFU / G of the present invention is the number of colonies contained in each G detection sample, and the CFU is a colony formation unit. The CFU / G described in the following examples generally refers to "equal to" or "not less than", in the actual use in the actual use of the number of live bacteria in the shelf life, in the effective range and the patients in the intestinal medium, the general product The number of bacteria is "not less than".

[0057] The following examples of the present invention have prepared for probiotic capsules, and the equipment used, including 3D moving mixers (Ji...

Embodiment 1

[0058] Example 1 Preparation of a probiotic preparation of the present invention

[0059] (1) Dry lyophilized germacte and excipient powder and excipient powder and excipients of Bacillus, Long Bacillus, Eosinophilus, and Swyncus are mixed; in this example, the excipient starch And lactose;

[0060] (2) Package (1) to the obtained mixture, the capsule is made into a capsule, and the capsule of the capsule is an enteric capsule, and each capsule contains 250 mg of mixed bacteria.

[0061] The live bacteria containing each capsule is not less than: Acid Bacillus 10 × 10 8 CFU / G, Long Bifurcum 4.0 × 10 8 CFU / G, Eosin Treatment 1.0 × 10 8 CFU / G, Swift Fungus 0.5 × 10 8 CFU / g.

[0062] After satisfying the number of live bacteria, the excipient is a margin, the mass ratio of the pregerative starch and lactose is 1: 1.

Embodiment 2

[0063] Example 2 Preparation of a probiotic preparation of the present invention

[0064] (1) Dry lyophilized germacte and excipient powder and excipient powder and excipients of Bacillus, Long Bacillus, Eosinophilus, and Swyncus are mixed; in this example, the excipient starch And lactose;

[0065] (2) Package (1) to the obtained mixture, the capsule is made into a capsule, and the capsule of the capsule is an enteric capsule, and each capsule contains 250 mg of mixed bacteria.

[0066] The live bacteria containing each capsule is not less than: Acid Bacillus 10 × 10 9 CFU / G, Long Bifurcum 4.0 × 10 9 CFU / G, Eosin Treatment 1.0 × 10 9 CFU / G, Swift Fungus 0.5 × 10 9 CFU / g.

[0067] After satisfying the number of live bacteria, the excipient is a margin, the mass ratio of the pregerative starch and lactose is 1: 1.

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Abstract

The invention discloses a probiotic composition for treating rapid eye movement sleep behavior disorder in patients with Parkinson's disease. Made; the number of viable Bacillus licheniformis not less than 10.0×10 8 CFU / g; the number of viable Bifidobacterium longum is not less than 4.0×10 8 CFU / g; the number of viable Lactobacillus acidophilus is not less than 1.0×10 8 CFU / g; the viable count of Enterococcus faecalis is not less than 0.5×10 8 CFU / g. The components of the present invention work synergistically to treat and improve the RBD symptoms and motor symptoms of PD patients, and solve the problem that the existing medicines cannot treat the motor symptoms and non-motor symptoms of PD patients at the same time, and the treatment effect has good sustainability and stability. . The invention effectively reduces the dosage of levodopa for PD patients, prevents patients from developing drug resistance to levodopa prematurely, and has a better protective effect on patients.

Description

Technical field [0001] The present invention relates to a probiotic composition, specifically a probiotic composition for the treatment of fast intraoperative sleep behavioral disorders and motion disorders in patients with Parkinson's disease and preparations obtained by the composition. Background technique [0002] Parkinson's Disease (PD) is a disease in slow pathology, static tremor, and muscle strength, main pathological characteristics is the loss of mid-brain black dopamine neurons and the residual neuronal cytoplasm The body (mainly for the wrong folded α-synaptic nuclear protein) is formed. The clinical manifestations include many non-exercise symptoms, such as constipation, fast-time sleep behavioral obstacles, RBD, olfactory reduction, cognitive impairment, depression, and more. [0003] Pd is a chronic progressive disease. At present, there are currently such as the treatment of the symptoms of Parkinson 's disease, mainly include the level of the neuronal synaptic g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61P25/16A61P25/20A61K35/741A61K35/742A61K35/745
CPCA61K35/747A61K35/745A61K35/742A61K35/741A61P25/16A61P25/20A61K2300/00A61P25/14
Inventor 脱厚珍杜艺彤许晓娇李悦高丹高婷薛云张铭凯
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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