Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Graphene-gold nanoflower composite material, and preparation method and application thereof

A technology of gold nanoflowers and composite materials, which can be applied in the fields of wave energy or particle radiation treatment materials, drug combinations, pharmaceutical formulations, etc., can solve the difficulty of photothermal material modification, poor biological affinity, and affect the biological application prospects of targeted tumor therapy. and other problems, to achieve the effect of good light-to-heat conversion properties

Inactive Publication Date: 2018-07-24
LINYI UNIVERSITY
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing photothermal materials have difficulties in further modification, resulting in poor bioaffinity, thus affecting their biological application prospects such as targeted tumor therapy.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Graphene-gold nanoflower composite material, and preparation method and application thereof
  • Graphene-gold nanoflower composite material, and preparation method and application thereof
  • Graphene-gold nanoflower composite material, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] The invention provides a kind of preparation method of graphene-gold nano flower composite material, comprises the following steps:

[0024] (1) adjust the pH value of chloroauric acid solution to be 10.5~11.5, obtain alkaline chloroauric acid solution;

[0025] (2) performing a reduction reaction with the alkaline chloroauric acid solution obtained in the step (1) with gold nanoparticles, hydroxylamine hydrochloride solution and graphene oxide to obtain a graphene-gold nanoflower composite material.

[0026] The invention adjusts the pH value of the chloroauric acid solution to 10.5-11.5 to obtain the alkaline chloroauric acid solution. In the present invention, the pH value of the chloroauric acid solution is preferably 11. In the present invention, the pH value of the chloroauric acid is adjusted within the above range to provide alkaline conditions for the subsequent reduction reaction.

[0027] In the present invention, the source of the chloroauric acid solution...

Embodiment 1

[0048] 1. Synthesis of gold species: 50mL 0.25mM chloroauric acid solution was placed in a 100mL three-hole flask, heated and stirred, condensed and refluxed to boiling, quickly added 0.75mL 1% sodium citrate, and then boiled for 20min, the color of the solution changed It is wine red, chloroauric acid is reduced, and gold species are synthesized. At this time, stop heating and cool to room temperature 25°C. The product is an aqueous solution of spherical gold nanoparticles; the particle size of gold nanoparticles is 25nm.

[0049] 2. Synthesis of graphene-gold nanoflower composites: First, 50 mL of HAuCl 4 The solution was adjusted to pH 11 with 1mol / L NaOH solution, HAuCl 4 The final concentration of the solution was 0.25 mM. Then 0.25 mL of NH 2 OH HCl solution (40mM) and 3.3mL gold seed aqueous solution (25nm, 3.75mM), 2mL 0.0017g / mL graphene oxide dispersion was added to 45mL0.25mM chloroauric acid solution, stirred at 500 rpm until the solution color From gray-pink to...

Embodiment 2

[0052] 1. Synthesis of gold species (25nm): 50mL of 0.25mM chloroauric acid was placed in a 100mL three-hole flask, heated and stirred, condensed and refluxed to boiling, quickly added 0.75mL of 1% sodium citrate, and then boiled for 20min, the solution The color becomes wine red, the chloroauric acid is reduced, and the gold species is synthesized. At this time, the heating is stopped and cooled to room temperature, and the product is an aqueous solution of spherical gold nanoparticles; wherein, the particle size of the gold nanoparticles is 25nm.

[0053] 2. Synthesis of graphene-gold nanoflower composites: First, 50 mL of HAuCl 4 Use 1mol / L NaOH solution to adjust the pH to 11, HAuCl 4 The final concentration was 0.25mM. Then 0.30 mL of NH 2 OH HCl solution (40mM) and 3.3mL gold seed (25nm, 3.75mM), the graphene oxide dispersion liquid of 2mL0.0017g / mL joins 45mL 0.25mM chloroauric acid solution, 500 turn / min speed stirs, until the solution color is by The gray-pink colo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a graphene-gold nanoflower composite material, and a preparation method and application thereof. The preparation method of the graphene-gold nanoflower composite material comprises the following steps: adjusting a pH value of chloroauric-acid solution to be 10.5-11.5, thus obtaining alkaline chloroauric-acid solution; enabling the alkaline chloroauric-acid solution to carryout reduction reaction with nano-gold particles, hydroxylammonium chloride solution and oxidized graphene, thus obtaining the graphene-gold nanoflower composite material. The graphene-gold nanoflowercomposite material prepared by the method has the beneficial effects that by a unique planar conjugate structure of graphene, an anticancer medicine (adriamycin) can be easily loaded in a II-II form,aptamer capable of targeting tumor cells can be modified on gold nanoflowe,r and can directly reach the tumor cells instead of acting on normal cells; meanwhile, both the graphene and the gold nanoflower have photothermal-conversion property, so that the tumor cells can be killed by thermotherapy.

Description

technical field [0001] The invention relates to the technical field of functional materials, in particular to a graphene-gold nanoflower composite material and its preparation method and application. Background technique [0002] Photothermal therapy, as one of the most commonly used methods for the treatment of clinical tumor diseases, is relatively safe, and the secondary damage to patients is far less than that of chemotherapy and radiotherapy. Photothermal therapy refers to the conversion of light energy into heat energy by some substances with strong absorption of light under laser irradiation to kill cancer cells. Photothermal therapy requires two key conditions: one is near-infrared light, which has strong tissue penetration ability and low tissue absorption rate, so it can penetrate deep tissues and reach many parts of the organism, so that it can give full play Therapeutic effect, due to its low tissue absorption rate, near-infrared light has only low lethality to ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/02A61P35/00
CPCA61K31/704A61K41/0052A61K47/02A61K2300/00
Inventor 刘静周宏张宁波张书圣
Owner LINYI UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com