Microbiome-derived diagnostic and therapeutic methods and systems for brain-craniofacial health-related disorders
A microbiological and craniofacial technology, applied in the direction of biological systems, biochemical equipment and methods, microbial measurement/inspection, etc., can solve problems such as infeasibility
Active Publication Date: 2022-06-03
PSOMAGEN INC
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Problems solved by technology
However, current methods and systems for analyzing the human microbiome and delivering therapeutic measures based on the insights gained still leave many unanswered questions
In particular, approaches to characterize certain health conditions based on microbiome compositional or functional diversity profiles, as well as subject-specific adaptation of treatments (e.g., probiotic treatments), are not yet available due to limitations of current technologies. Row
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[0074] The inventors have discovered that characterization of an individual's microbiome can be used to detect microbiomes that are indicative of insomnia, light sleep, headache, sinusitis or poor concentration. For example, individuals with indications of, or suspected of having, insomnia, light sleep, headache, sinusitis, or attention deficit may be tested to confirm or provide further evidence to Support or refute the subject's diagnosis. As another example, individuals can be assayed to determine whether they have a microbiome that may increase the risk of insomnia, light sleep, headache, sinusitis, or poor concentration. As another example, an individual with or with a history of insomnia, light sleep, headache, sinusitis or attention deficit can be tested to determine whether the microbiome is likely to be a Predisposing factors, or whether they may increase the frequency or severity of insomnia, light sleep, headaches, sinusitis, or poor concentration.
[0075] As use...
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The present invention provides for detecting one or more brain-craniofacial health problems and / or determining, displaying or facilitating treatment of brain-craniofacial health problems by characterizing an individual's microbiome, monitoring the impact of said microbiome methods, compositions and systems. Also provided are methods, compositions and systems for generating and comparing microbiome composition and / or functional diversity datasets. Also provided are methods, compositions and systems for generating characterization models and / or treatment models for insomnia problems, light sleep problems, headache problems, sinus problems, or poor concentration problems.
Description
[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This patent application claims US Provisional Application No. 62 / 216,016, filed on September 9, 2015, US Provisional Application No. 62 / 216,028, filed on September 9, 2015, and US Provisional Application No. . 62 / 215,939, U.S. Provisional Application No. 62 / 216,035, filed Sep. 9, 2015, and U.S. Provisional Application No. 62 / 216,042, filed Sep. 9, 2015, the disclosures of each of the above U.S. Provisional Applications Incorporated herein in its entirety and for all purposes. Background technique [0003] The microbiome is the ecological community of commensal, symbiotic, and pathogenic microorganisms associated with an organism. The human microbiome contains more microbial cells than human cells, but the characterization of the human microbiome is still in its infancy due to limitations in sample processing techniques, genetic analysis techniques, and resources for processing large amounts of data . Nonetheless, the m...
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IPC IPC(8): C12Q1/689G16B5/00G16B30/00G16B50/10G16B50/30G16B20/20G16B30/10G16B40/20
CPCC12Q1/689C12Q2600/106C12Q2600/158G16H50/50G16H50/20G16H20/70G16B20/00G16B30/00G16B40/00G16B30/10G16B20/20G16B40/20Y02A90/10
Inventor 扎迦利·阿普特杰西卡·里奇曼丹尼尔·阿尔莫纳西德斯亚沃什·瑞兹万·贝赫巴哈尼
Owner PSOMAGEN INC