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A kind of preparation method and application of hyperbranched polyester-based polyurethane medical adhesive

A technology of hyperbranched polyester and polyurethane, applied in applications, surgical adhesives, medical science, etc., can solve the problems of general adhesion, easy to cause infection, low adhesion strength of medical tapes, etc., and achieve the adjustable range of modulus. Large size, good biocompatibility, and rapid repair effect

Active Publication Date: 2020-01-14
广州迅合医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical sutures need to be operated by professional doctors, causing pain to patients when using them, difficult to repair microtrauma, and easy to cause infection
Medical adhesive tape has low adhesion strength, poor adaptability to complex wounds, and it is difficult to completely cover the wound, resulting in subsequent bacterial invasion and infection
Commercial bioglues mainly include fibrin glue, α-cyanoacrylate, etc. Fibrin glue has good biological safety, but its adhesion is general and expensive; although α-cyanoacrylate has fast curing speed and high strength, it has Certain biological toxicity, and will prevent wound healing, high modulus is brittle, difficult to adapt to the tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The first step, in the pass N 2 1. Add 10g H101 (20mmol, 120mmol of -OH) into a round bottom flask under stirring environment, then slowly add 3.17ml (40mmol) acryloyl chloride and equimolar amount of triethylamine dropwise to it, react for more than 24h, separate and purify Precursor 1. The second step, in the pass N 2 1. Add 4.52g LDI (20mmol) into a round bottom flask under stirring environment, then slowly drop 2g PEG200 (10mmol) into it, and react at 60°C for >12h to obtain precursor 2. The third step is to pass N 2 1. Add 6.52g (10mmol, 20mmol of -NCO) precursor 2 into a round-bottomed flask under stirring environment, and then slowly add 1.52g (2.5mmol, 10mmol of -OH) of precursor 1 to it to obtain a Hyperbranched polyester-based polyurethane medical adhesive with double bonds. The fourth step is to mix the medical adhesive obtained in the third step with 0.1wt% photoinitiator i2595 evenly, and store it away from light until use. When in use, apply the medic...

Embodiment 2

[0021] The first step, in the pass N 2 1. Add 12g H2O1 (20mmol, 120mmol of -OH) into a round bottom flask under stirring environment, then slowly add 6.34ml (80mmol) acryloyl chloride and equimolar amount of triethylamine dropwise to it, react for more than 24h, separate and purify Precursor 1. The second step, in the pass N 2 1. Add 4.52g LDI (20mmol) into a round bottom flask under stirring environment, then slowly drop 2g PEG200 (10mmol) into it, and react at 60°C for >12h to obtain precursor 2. The third step is to pass N 2 1. Add 3.586g (5.5mmol, 11mmol of -NCO) precursor 2 into a round bottom flask under stirring environment, and then slowly add 1.52g (2.5mmol, 10mmol of -OH) of precursor 1 dropwise to it to obtain a Hyperbranched polyester-based polyurethane medical adhesive containing double bonds. The fourth step is to mix the medical adhesive obtained in the third step with 0.5wt% photoinitiator i2595 evenly, and store it in the dark for later use. When in use, ...

Embodiment 3

[0023] The first step, in the pass N 2 1. Add 18.4g H3O1 (20mmol, 120mmol of -OH) into a round bottom flask under stirring environment, then slowly add 4.755ml (60mmol) acryloyl chloride and equimolar amount of triethylamine dropwise to it, react for more than 24h, separate and purify Precursor 1 was obtained. The second step, in the pass N 2 1. Add 4.52g LDI (20mmol) into a round bottom flask under stirring environment, then slowly drop 2g PEG200 (10mmol) into it, and react at 60°C for >12h to obtain precursor 2. The third step is to pass N 2 1. Add 4.89g (7.5mmol, 15mmol of -NCO) precursor 2 into a round-bottomed flask under stirring environment, and then slowly add 1.52g (2.5mmol, 10mmol of -OH) of precursor 1 dropwise to it to obtain a Hyperbranched polyester-based polyurethane medical adhesive containing double bonds. The fourth step is to mix the medical adhesive obtained in the third step with 0.2wt% photoinitiator i2595, and store it in the dark until use. When in...

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PUM

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Abstract

The invention discloses a preparation method and application of a hyperbranched polyester based polyurethane medical adhesive. The preparation method comprises the following steps: 1) taking hydroxyl-terminated hyperbranched polyester and acryloyl chloride to react, and obtaining a series of double-bond modified precursors 1 through a regulation and control ratio, wherein the mol ratio of -OH in the hydroxyl-terminated hyperbranched polyester to the acryloyl chloride is 1 to (2 to 4); 2) feeding diisocyanate and polyethylene glycol according to the mol ratio of 2 to 1 and reacting to obtain aprecursor 2; 3) taking the precursor 1 and the precursor 2 to react according to the ratio of a -OH functional group number of the precursor 1 to a -NCO functional group number of the precursor 2 of 1to (1.1 to 2.0), so as to obtain a double-bond-containing hyperbranched polyester based polyurethane medical adhesive; 4) uniformly mixing the hyperbranched polyester based polyurethane medical adhesive with 0.1 to 0.5 weight percent of photoinitiator i2595 and preserving in a dark place for later use. The medical adhesive prepared by the preparation method has no toxicity and harms, good biocompatibility and a strong chemical adhesive force on human tissues.

Description

technical field [0001] The invention relates to the technical field of medical glue, in particular to a preparation method and application of a hyperbranched polyester-based polyurethane medical adhesive. Background technique [0002] Existing repair methods for human tissue trauma: surgical suture, medical tape and commercial bioglue. Surgical suturing requires professional doctors to operate, causing pain to patients when using it, difficult to repair microtrauma, and easy to cause infection. Medical adhesive tape has low adhesion strength, poor adaptability to complex wounds, and it is difficult to completely cover the wound, resulting in subsequent bacterial invasion and infection. Commercial bioglues mainly include fibrin glue, α-cyanoacrylate, etc. Fibrin glue has good biological safety, but its adhesion is general and expensive; although α-cyanoacrylate has fast curing speed and high strength, it has Certain biological toxicity, and will prevent wound healing, high ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/68C08G18/48C08G63/91A61L24/00A61L24/04
CPCA61L24/001A61L24/046C08G18/48C08G18/68C08G63/91
Inventor 施雪涛宣承楷
Owner 广州迅合医疗科技有限公司
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