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A kind of preparation method and application of Si-based polyurethane medical adhesive

A polyurethane and adhesive technology, used in applications, surgical adhesives, medical science, etc., can solve the problems of easy infection, patient pain, high price, etc., and achieve good biocompatibility, good process controllability, Simple preparation process

Active Publication Date: 2019-08-20
广州迅合医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing means of repairing human tissue trauma include surgical suture, medical tape and commercial bioglue. Surgical suture causes pain to the patient, is difficult to repair microtrauma, and is easy to cause infection
The strength of medical tape is too low, and the adaptability to complex wounds is poor
Commercial bioglues mainly include fibrin glue, α-cyanoacrylate, etc. Fibrin glue has good biological safety, but its adhesion is general and expensive; although α-cyanoacrylate has fast curing speed and high strength, it has Certain biological toxicity, high modulus, difficult to adapt to tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation method of the Si-based polyurethane medical adhesive provided in this example is as follows: firstly, the compound with silicon oxygen as the main chain and the terminal group containing active hydrogen functional group reacts with the compound containing isocyanate functional group to obtain the terminal group of The precursor of isocyanate; then react the precursor with a cross-linking agent containing active hydrogen functional groups to obtain the required isocyanate-terminated Si-based polyurethane medical adhesive. By changing the cross-linking density, Si-based polyurethane medical adhesive can be realized Modulus adjustment of the agent. Among them, the main chain is silicon oxide, the terminal group contains active hydrogen functional groups, the average number of active hydrogens is ≥ 2, and the NH 2 -(CH 2 ) m -O-(Si(CH 3 ) 2 -O) n -(CH 2 ) m -NH 2 , HO-(CH 2 ) m -O-(Si(CH 3 ) 2 -O) n -(CH 2 ) m -OH, HS-(CH 2 ) m -O-(Si(CH 3 ...

Embodiment 2

[0022] The difference with embodiment 1 is that this embodiment is in a pass N 2 1.68g HDI was added to a two-necked round bottom flask with a temperature of 60°C and a stirring rate of 2000rpm, and 1.29g NHDI was added in 1 hour by slow dropwise addition. 2 -(CH 2 ) 6 -O-(Si(CH 3 ) 2 -O) 4 -(CH 2 ) 6 -NH 2 , reacted for 2 hours to obtain the precursor; 0.20g glycerol and 0.02g melamine were dissolved in 1.5mlTHF, the reaction temperature was 20°C, added in 1 hour by slow dropwise addition, and then reacted for 3 hours, the obtained The adhesives were sealed and stored at room temperature under nitrogen. When in use, apply the adhesive on two pieces of wet tissue and apply pressure for about 1 minute to obtain a good bonding effect.

Embodiment 3

[0024] The difference with embodiment 1 is that this embodiment is in a pass N 2 2.36g of LDI was added to a two-necked round bottom flask with a temperature of 60°C and a stirring rate of 2000rpm, and 1.04g of NH was added in 1 hour by slow dropwise addition. 2 -(CH 2 ) 3 -O-(Si(CH 3 ) 2 -O) 4 -(CH 2 ) 3 -NH 2 , reacted for 2 hours to obtain the precursor; 0.18g glycerol and 0.02g melamine were dissolved in 1.5mlTHF, the reaction temperature was 20°C, added in 1 hour by slow dropwise addition, and then reacted for 3 hours, the obtained The adhesives were sealed and stored at room temperature under nitrogen. When in use, apply the adhesive on two pieces of wet tissue and apply pressure for about 1 minute to obtain a good bonding effect.

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PUM

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Abstract

The invention discloses a preparation method and an application of a Si-based polyurethane medical adhesive. Firstly, a compound which takes Si-O as a main chain and contains an activated hydrogen functional group at the terminal reacts with a compound containing an NCO functional group, and an NCO-terminated precursor is obtained; then, the precursor reacts with a crosslinking agent containing anactivated hydrogen functional group, the NCO-terminated Si-based medical polyurethane adhesive can be obtained, and modulus adjustment of the Si-based medical polyurethane adhesive can be realized bychanging the crosslinking density. The prepared Si-based polyurethane medical adhesive is non-toxic and harmless, has good biocompatibility, has high chemical adhesion to human tissue and can be applied to repair of different human soft and hard tissue.

Description

technical field [0001] The invention relates to the technical field of medical glue, in particular to a preparation method and application of a Si-based polyurethane medical adhesive. Background technique [0002] The existing means of repairing human tissue trauma include surgical sutures, medical tapes and commercial bioglues. Surgical sutures cause pain to patients when used, are difficult to repair micro-trauma, and are easy to cause infection. The strength of medical tape is too low and its adaptability to complex wounds is poor. Commercial bioglues mainly include fibrin glue, α-cyanoacrylate, etc. Fibrin glue has good biological safety, but its adhesion is general and expensive; although α-cyanoacrylate has fast curing speed and high strength, it has Certain biological toxicity and high modulus are difficult to adapt to tissues. Therefore, people expect to develop a medical glue with good biological safety, adjustable modulus, good adaptability to different tissues, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04C08G18/38
Inventor 施雪涛宣承楷
Owner 广州迅合医疗科技有限公司
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