Preparation method of extract of granules containing radix scrophulariae, radix ophiopogonis, radix glycyrrhizae and radix platycodonis

Abstract

The invention relates to a preparation method of extract of granules containing radix scrophulariae, radix ophiopogonis, radix glycyrrhizae and radix platycodonis. The preparation method is characterized by comprising the following processing steps: first, soaking radix scrophulariae for 2-3 h, mixing the soaked radix scrophulariae with radix ophiopogonis, radix glycyrrhizae and radix platycodonis, adding 9-10 folds of water, carrying out soaking for 25-30 min, carrying out heating till the boiling state is achieved, carrying out first-time extracting, carrying out filtering, adding 9-10 foldsof water into the obtained filter residue, carrying out heating till the boiling state is achieved, carrying out second-time extracting, carrying out second-time filtering, adding 7-8 folds of waterinto the obtained filter residue, carrying out heating till the boiling state is achieved, carrying out third-time extracting, mixing the filtrates obtained after the three times of filtering, carrying out concentrating, carrying out standing, carrying out centrifugalizing, carrying out re-concentrating, and collecting the extract. According to the preparation method provided by the invention, themethod of shortening the soaking time is adopted for treating the traditional Chinese medicinal materials of the granules containing radix scrophulariae, radix ophiopogonis, radix glycyrrhizae and radix platycodonis, so that the content of harpagoside in the extract of the granules containing radix scrophulariae, radix ophiopogonis, radix glycyrrhizae and radix platycodonis is improved, and meanwhile, the time consumed by the process is shortened correspondingly.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of xuanmai ganju granule extract. Background technique [0002] Xuanmai Ganju Granules are composed of four Chinese herbal medicines: Scrophularia scrophulariae, licorice, Ophiopogon japonicus and platycodon grandiflorum. Functions and indications: clearing heat and nourishing yin, eliminating phlegm and relieving throat. For hyperactivity of fire due to deficiency of yin, rising of asthenic fire, dry mouth and nose, sore throat. It is a classic traditional Chinese medicine prescription, and it is included in the 2015 edition of the "Chinese Pharmacopoeia". 24 h 30 o 11 ), each bag shall not be less than 25mg. [0003] The content of harpagoside in Xuanmai Ganju granule extract directly affects the content of the finished product. The content of harpagoside comes from the medicinal material Scrophularia scrophular...

AI Technical Summary

Problems solved by technology

[0004] In the prior art, Xuanmai Ganju granules are usually prepared by soaking, soaking for a long time (more than 3 hours), and decocting for extraction. This method has the following problems: 1. The active ingredient Haba in Scrophulariaceae cannot be extracted. Rusticin was fully extracted, resulting in a lower content of harpagoside in the extract of Xuanmai Ganju granules. According to the calculation, the content of harpagoside in each batch of Xuanmai Ganju granule extract was much lower than the theory of harpagoside in the medicinal materials of Scrophulariaceae Scrophulariae. content; 2. The soaking time is long, at least 3 hours, resulting in a long time-consuming process