A microfluidic chip for peeling double emulsion droplet shell and its application method

Abstract

The invention discloses a microfluidic chip with a release double-emulsion droplet shell layer and an application method thereof. All a thin-shell double-emulsion droplet outlet, a shell layer single-emulsion droplet outlet, a double-emulsion droplet injection port, a speed control flow inlet, a thin-shell double-emulsion droplet outlet connection, a shell layer single-emulsion droplet outlet connection, a double-emulsion droplet injection inlet connection and a speed control flow inlet connection are hole structures in a main solid structure. All a thin-shell double-emulsion droplet observation chamber, a shell layer single-emulsion droplet observation chamber, an outer circular branch passage, an inner circular branch passage, a shell layer release bifurcation, a double-emulsion dropletupstream passage, a conical speed control flow passage, a double-emulsion droplet acceleration passage and an arc centrifugal passage are groove structures in the main solid structure. A mask is manufactured; a model is etched on a solid base plate by means of photoetching, etching and the like; device packaging is then performed. A macromolecular material is used as a chip material to manufacturea macromolecular chip that is pasted to a glass slide; the microfluidic provided herein is obtained.

Description

technical field [0001] The invention relates to a microfluidic chip for stripping double emulsion droplet shells and a method for using it, and belongs to the field of droplet microfluidic technology based on microfluidic chips. Background technique [0002] Double emulsion droplet is a highly structured and complex multiphase system in which discrete phase droplets are wrapped with smaller dissimilar solution droplets. Its unique core-shell structure can effectively protect the sample in the core from the complex external environment. Drug carriers, self-healing technology, and photonic crystals all have great application potential. [0003] Droplet microfluidic technology is a new technology developed in recent years to study the generation, manipulation and application of micron-scale micro-droplets. This technology has the characteristics of stability, easy operation and wide application range. It has been widely used in many fields such as drug delivery, disease preven...

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Problems solved by technology

[0004] However, there is mutual coupling between the inner and outer droplet sizes during the generation of double emulsion droplets. For example, reducing the inner droplet size is usually accompanied by an increase in the thickness of the double emulsion droplet shell, which in turn leads to an increase in the defect rate of microcapsule products, which makes single It is difficult to meet the needs of some application fields with the generation device, which limits the further popularization of the technology of microfluidic method to generate double emulsion droplets in the industry

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