Method for establishing controllable multiple-fracture aortic dissection model

A technology of aortic dissection and establishment method, which is applied in the field of establishment of controllable multiple-break aortic dissection model, which can solve the problems of low success rate of the model, inability to control the position and size of the original break, and high mortality rate

Inactive Publication Date: 2018-08-24
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In previous studies, the establishment methods of aortic dissection model in pigs or dogs include (1) thoracotomy to expose the aorta, and to create the original breach through mechanical damage to the aorta. The disadvantage is that the distal breach and the secondary breach in the middle cannot be controlled. location and size
(2) The dissection is induced by intravenous injection of drugs such as elastase, which has the disadvantages of low success rate of the model, high mortality rate, and the inability to control the position and size of the original breach, intermediate secondary breach and distal breach
[0006] In the prior art, there is no report about the establishment method of the controllable multiple-tear aortic dissection model of the present invention

Method used

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  • Method for establishing controllable multiple-fracture aortic dissection model
  • Method for establishing controllable multiple-fracture aortic dissection model
  • Method for establishing controllable multiple-fracture aortic dissection model

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Example 1 Establishment of a single-shot breach type B aortic dissection model

[0033]Intravenous ketamine combined with strong inhaled anesthetic (isoflurane) was used for general anesthesia and endotracheal intubation. The hybrid operating room was connected to an anesthesia machine for mechanical positive pressure ventilation, and anesthesia was inhaled during the operation for maintenance. Animals (Shanghai Landrace pigs) were placed on the radiography operating table in the right lateral position, and the left chest was incised at the 5-7 intercostal space obliquely. The descending aorta was exposed about 20cm below the level of the ductus arteriosus ligament, controlled by a plastic band; the intercostal arteries (1 to 3 pairs) were ligated, and the azygos vein accompanying the middle section of the descending aorta was separated. Aortic forceps completely block the proximal and distal ends of the descending aorta, cut the descending aorta longitudinally (1 / 3 to...

Embodiment 2

[0035] Example 2 Establishment of controllable multiple breach type B aortic dissection model

[0036] The CTA examination of thoracoabdominal aorta was re-examined within 2 to 3 weeks after the operation of the animal model with a single breach (attached figure 1 ), to evaluate the distribution of true and false lumens, the progression of dissection, and the involvement of branch vessels. The location and size of the secondary breach to be constructed are determined before the operation.

[0037] Intravenous ketamine combined with strong inhaled anesthetic (isoflurane) was used for general anesthesia and endotracheal intubation, and the animals were placed supine and tied to the contrast operating table. The anesthesia machine was connected to the compound operating room for mechanical positive pressure ventilation, and anesthesia was inhaled during the operation for maintenance. The right femoral artery was punctured with the Seldinger method, and a 6F catheter sheath was ...

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Abstract

The invention discloses a method for establishing a controllable multiple-fracture aortic dissection model. The method includes the steps of 1, establishing a single-fracture B-type aortic dissectionmodel; 2, establishing a controllable multiple-fracture B-type aortic dissection model. Different levels can be selected for the descending aorta, mechanical damage is adopted for separating differentlayers of membranes in the aortic blood vessels, and distal endometrium face-to-face suture is adopted for shaping original dissection fractures different in size so that not only can animal models for different anatomical locations of the human body B-type dissection be simulated, but also the effect of different fracture sizes on progression of the dissection can be observed. By firstly constructing a single-fracture thoracic aortic dissection model and further evaluating the progress of the dissection through CT and DSA radiography within 2-3 weeks after surgery, different positions of thedissection can be selectively chosen, and secondary fractures are reshaped by means of a guidewire catheter technique. The reproducibility and success rate are high, a new idea is provided for the clinical and basic research of the B-type dissection, and a good animal model is provided for animal experiments before new stent materials appear on the market.

Description

technical field [0001] The invention relates to the technical field of animal models, in particular to a method for establishing a controllable multiple-break aortic dissection model. Background technique [0002] Aortic dissection (Aortic Dissection, AD) refers to the rupture of the aortic intima under the action of various factors, and the blood in the blood vessel enters the weak middle layer of the aortic wall through the aortic intima rupture, with or without A life-threatening disease with longitudinal medial tear and separation of the normal arterial wall, resulting in hemodynamic disturbance. Aortic dissection is a fatal emergency and critical illness. Its onset is sudden, and it can cause aortic rupture in a short period of time, leading to shock and death, or severe complications due to ischemia of important distant organs. Therefore, research on the pathogenesis and treatment of AD has always been a hot spot in the field of vascular disease research. [0003] Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 郭宝磊董智慧符伟国郭大乔陈斌史振宇
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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