Segmentation method of pathological section unconventional cells based on multi-scale hybrid segmentation model

A technology for segmentation models and pathological slices, applied in image analysis, image data processing, character and pattern recognition, etc. It can solve the problems of small number of pixels, large number of negatives, irregular size, etc., to achieve good popularization and reduce work. high-volume, high-precision effects

Active Publication Date: 2018-08-24
ZHEJIANG UNIV
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Benefits of technology

This patented technique described in this patents allows researchers to easily identify specific areas within image samples based on their size or shape without having access to specialized equipment like histology labs. It also improves upon existing techniques while reducing labor costs compared to current technologies. Overall, it provides technical benefits over conventional approaches.

Problems solved by technology

The technical problem addressed in this patents relates to improving the performance of semiconductor devices that can accurately identify specific areas within images without being affected by noise from surrounding background structures like walls or objects during scanning processes. This requires accurate and efficient techniques for analyzing complex datasets containing both grayscale and color feature maps obtained with different sensors.

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  • Segmentation method of pathological section unconventional cells based on multi-scale hybrid segmentation model
  • Segmentation method of pathological section unconventional cells based on multi-scale hybrid segmentation model
  • Segmentation method of pathological section unconventional cells based on multi-scale hybrid segmentation model

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Embodiment Construction

[0052] In order to further understand the present invention, a method for unconventional cell segmentation of pathological slices based on a multi-scale hybrid segmentation model provided by the present invention will be described in detail below in conjunction with specific implementation methods, but the present invention is not limited thereto. Non-essential improvements and adjustments made under the core guiding ideology still belong to the protection scope of the present invention.

[0053] An unconventional cell segmentation method for pathological slices based on a multi-scale hybrid segmentation model, the specific steps are:

[0054] 1) Pathological slice preprocessing and valid area discrimination

[0055] The present invention adopts pathological slices with 20x magnification as input data, divides them into regions with a pixel resolution of 2048*2048, and stores them as images respectively.

[0056] Convert the region with a pixel resolution of 2048*2048 above i...

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Abstract

The invention discloses a segmentation method of pathological section unconventional cells based on a multi-scale hybrid segmentation model. The method comprises steps that positive and negative samples are respectively scaled to low-resolution, medium-resolution and high-resolution images, the full convolutional network algorithm is utilized for training to acquire a convergent low-resolution segmentation model, a medium-resolution segmentation model and a high-resolution model; a multi-scale hybrid segmentation model is acquired through fusion by a model integration method; after the effective discriminating area of a new pathological section is processed through utilizing the data enhancement method during testing, the processed effective discriminating area is inputted to the multi-scale hybrid segmentation model, the probability of each pixel in the effective segmentation area is outputted, pixels with probability values greater than the threshold t are taken as abnormal cell pixels and are recorded as 1, remaining pixels are taken as normal cell pixels and are recorded as 0, binary images predicted by the multi-scale hybrid segmentation model are acquired, and post-processingon the binary images is carried out to acquire the final segmentation result. The method is advantaged in that high precision is realized, and a Dice value is above 0.869.

Description

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Claims

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Application Information

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Owner ZHEJIANG UNIV
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