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Flow cell for analyzing particles in a liquid to be examined

A technology to be detected and liquid, which is applied in the analysis of materials, biological particle analysis, individual particle analysis, etc., can solve the problem of no enrichment of weak set components, and achieve the effect of high viscosity and efficient separation of particles

Active Publication Date: 2018-08-31
SIEMENS HEALTHCARE GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the mentioned methods have hitherto not been used for the enrichment of weakly concentrated constituents of the liquid to be tested

Method used

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  • Flow cell for analyzing particles in a liquid to be examined
  • Flow cell for analyzing particles in a liquid to be examined
  • Flow cell for analyzing particles in a liquid to be examined

Examples

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Embodiment Construction

[0055] combine Figure 1 to Figure 3 A first embodiment of the apparatus 1 for detecting white blood cells WBC is explained.

[0056] figure 1 shows a top view of a microfluidic channel system 1 used as a flow chamber for detecting white blood cells WBC, which represents a method for detecting particles in a liquid to be detected according to an embodiment of the present invention equipment. The microfluidic channel system comprises a separation stage S1, a process stage S2 connected after the separation stage and an acquisition unit S3 connected after the process stage. The top view is implemented for the x / y plane. Here, the flow direction of the liquid to be detected is the x direction. In addition, in figure 1 Also shown in side view, i.e. in the x / z plane, is the part drawn on the right comprising the flow path F, the process level S2, and the acquisition unit of the microfluidic channel system 1 at the bottom right of the figure S3.

[0057] The microfluidic chann...

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PUM

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Abstract

The invention relates to a device (1, 2) for examining particles (RBC, WBC, PLT) in a liquid to be examined, comprising a flow passage (F) through which the liquid (BL) to be examined is moved. The flow passage (F) has at least one inlet (E3, E4) through which at least one sheath fluid (PF1, PF2) flows into the flow passage (F) such that the at least one sheath fluid (PF1, PF2) forms at least onesheath flow (MS1, MS2) in the flow passage (F). The device (1, 2) further comprises a wave generating device (WE2) for piezoacoustically generating sound waves (AW) which propagate through the flow passage (F) transversely to the flow direction of the liquid (BL) to be examined and form wave nodes (KN) on a monitoring plane (BA) such that particles (WBC, RBC, PLT) to be examined of the liquid (BL)to be examined are moved onto the monitoring plane (BA) and accumulate thereon on the basis of the pressure effect of the sound waves (AW) in the transversal direction.

Description

technical field [0001] The invention relates to a device for detecting particles in a liquid to be detected. Furthermore, the invention relates to a device for microscopic observation of particles in a liquid to be examined. The invention also relates to a method for detecting particles in a liquid to be detected. Furthermore, the invention relates to the use of a flow chamber and a wave generating device for piezoacoustic generation of sound waves. Background technique [0002] Blood is made up of various components that are present in varying concentrations in the blood. Red blood cells (also called erythrocytes) make up 98% of the blood, while platelets (also called thrombocytes) comprise 1.9% of the blood, and white blood cells (also called leukocytes) make up only 0.1% of the blood. When it is desired to detect only a low proportion of blood components, namely platelets or white blood cells, there are two possibilities for the procedure. Alternatively, red blood cel...

Claims

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Application Information

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IPC IPC(8): G01N15/14G01N15/00G01N15/10
CPCG01N2015/1415G01N2015/142G01N2015/1006G01N15/1459G01N15/147G01N15/1404G01N2015/018G01N2015/012G01N2015/016G01N15/1433
Inventor 奥利弗·哈德恩卢卡斯·里克特马蒂亚斯·乌格勒
Owner SIEMENS HEALTHCARE GMBH