A device for assisting drug administration in corneal cross-linking surgery

Abstract

The invention discloses a drug administration auxiliary device for cornea crosslinking surgery. The device comprises a liquid storage structure for storing liquid medicine and an adsorbing structure for being adsorbed to the surfaces of eyeballs; the liquid storage structure is arranged on the adsorbing structure, a heating coil is installed on the liquid storage structure, liquid medicine injected into the liquid storage structure is temporarily stored above corneas, hydraulic pressure of the accumulated liquid medicine accelerates adsorption of the corneas for riboflavin in the liquid medicine, and the heating coil generates a temperature field under an alternating magnetic field to promote adsorption of the corneas for riboflavin in the liquid medicine. The utilization rate and the adsorption degree of the corneas for the riboflavin solution in the cornea crosslinking surgery can be increased.

Description

technical field [0001] The invention relates to a device for assisting drug administration in corneal cross-linking operation. Background technique [0002] Ultraviolet A riboflavin corneal cross-linking therapy is a new method that uses 370 nm ultraviolet A light and photosensitizer riboflavin to induce cross-linking of corneal stroma collagen fibers, thereby improving corneal hardness and changing biological properties, and is used for the treatment of keratoconus diseases and dilated corneal disease. [0003] The photosensitizer riboflavin (vitamin B2) is excited to the triplet state under the action of ultraviolet light with a wavelength of 370 nm, producing reactive oxygen species mainly composed of singlet oxygen. Reactive oxygen species can react with various molecules to induce chemical cross-linking reactions between amino groups (groups) of collagen fibers (type II photochemical reaction), thereby increasing the mechanical strength of collagen fibers and the abili...

AI Technical Summary

Problems solved by technology

Therefore, the absorption of riboflavin has a great influence on the cross-linking results. Although many techniques, such as continuous ultrasound induction and iontophoresis, have been proven to effectively induce riboflavin to soak into the corneal stroma, in the actual operation process, often Simply apply riboflavin to the cornea intermittently, it is easy to lose, and its absorption efficiency is very low, so that the final cross-linking effect is not ideal

[0004] The tight junction of corneal epithelial cells makes it difficult for riboflavin solution to penetrate into corneal stromal cells, and the degree of absorption of riboflavin solution largely determines the final effect of cross-linking. Given that surgery is different from research, the method used is often very different. Simple instillation of riboflavin solution, most of the riboflavin is directly lost and wasted, and not much can be absorbed into the matrix, and the final surgical effect is difficult to control

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