Method for determining residues of seven sulfonamide antibiotics in sediment sample

A sediment and sulfonamide technology is applied in the field of determination of 7 kinds of sulfonamide antibiotic residues in sediment samples, which can solve the problems of poor anti-interference ability and insufficient sensitivity, and achieve the improvement of accuracy, high detection sensitivity and grinding precision. Effect
CN108535384AInactive Publication Date: 2018-09-14NANJING INST OF ENVIRONMENTAL SCI MINIST OF ECOLOGY & ENVIRONMENT OF THE PEOPLES REPUBLIC OF CHINA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING INST OF ENVIRONMENTAL SCI MINIST OF ECOLOGY & ENVIRONMENT OF THE PEOPLES REPUBLIC OF CHINA
Publication Date
2018-09-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of determination of antibiotics in sediments, in particular to a method for determining the residues of seven sulfonamide antibiotics in a sediment sample.In the method, the high-performance liquid chromatography-mass spectrometry is utilized in combination with accelerated solvent extraction and solid-phase extraction for detecting the residues of seven sulfonamide antibiotics in the sediment sample. The sediment sample is subjected to accelerated solvent extraction and solid-phase extraction purification, a high-performance liquid chromatograph-mass spectrometer is used for MRM ion mode analysis, and an external standard method is used for quantification. The method is low in detection limit, good in stability, high in recovery rate and highin detection sensitivity, is used for rapid screening of seven sulfonamide antibiotics in sediments and can basically meet the requirement for detecting target substance residues in sediments.
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Description

technical field

[0001] The invention relates to the technical field of water environment detection, in particular to a method for determining the residues of seven sulfonamide antibiotics in sediment samples. Background technique

[0002] In addition to being used for human health, antibiotics are also used as animal production accelerators. According to reports, the annual consumption of antibiotic raw materials in my country is about 180,000 tons, which is equivalent to 138g per capita per year, which is 10 times that of the United States. Sulfonamide antibiotics are one of the most widely used antibiotics, which are derivatives containing p-aminobenzenesulfonamide structure. These drugs have a broad antibacterial spectrum and have inhibitory effects on most Gram-positive and Gram-negative bacteria. It mainly includes antibiotics such as acesulfame, sulfamethazine, sulfamethoxazole, sulfamethoxypyridazine, and sulfabenzopyrazole. Due to the widespread use of such substan...

Claims

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