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Skin external use type ray protection spray and preparation method thereof

A radiation protection and spray technology, which is applied to skin diseases, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of skin and mucous membrane tissue radiation damage, decreased control rate, and prolongation of the total treatment course. , to achieve the effect of reducing damage, enhancing cell vitality, and improving self-resistance

Inactive Publication Date: 2018-10-16
GUANGXI XINYE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the indirect effect of medical rays on the skin and mucous membrane tissue of the irradiated part during radiotherapy, that is, the medical ray ionizes the water molecules in the irradiated part of the tissue to generate a large number of toxic free radicals, which attack the irradiated part Tissue cells, which in turn cause radiation damage to the skin and mucous membranes at the irradiated site
It has been reported that acute radiation skin and mucous membrane injury is an important factor affecting the effect of tumor treatment. For example, patients with head and neck tumors undergoing radiotherapy have local skin and mucous membrane acute radiation injury, which can prolong the total course of treatment for up to 14 days, and local tumor control rate decreased by 13% to 24%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A kind of radiation protection spray for skin external use, described every 100 milliliters of skin radiation protection spray for external use is made up of following raw materials:

[0043] Trehalose 0.5g

[0044] Sodium alginate oligosaccharides 0.1g

[0045] Sage Extract 0.005g

[0046] Tea polyphenols 0.25g

[0047] L-Ascorbic acid 2-glucoside 0.35g

[0048] Sodium pyrrolidone carboxylate 2.5g

[0049] Purified water balance.

[0050] The sage extract is the ethanol extract of sage.

[0051] The sage extract is dried sage, crushed, soaked in water at 60°C for 6 hours, filtered, added 5 times by weight of 70% ethanol solution to reflux and extracted twice, each time for 3 hours, and the combined filtrate was evaporated to dryness to obtain .

[0052] The preparation method of the above-mentioned radiation protection spray for external use on the skin is to weigh the sodium pyrrolidone carboxylate of the formulation amount and dissolve it in 80ml of purified w...

Embodiment 2

[0054] A kind of radiation protection spray for skin external use, described every 100 milliliters of skin radiation protection spray for external use is made up of following raw materials:

[0055] Trehalose 2g

[0056] Sodium Alginate Oligosaccharides 3g

[0057] Sage Extract 2g

[0058] Tea polyphenols 0.01g

[0059] L-Ascorbic acid 2-glucoside 0.005g

[0060] Sodium pyrrolidone carboxylate 0.1g

[0061] Purified water balance.

[0062] The sage extract is the ethanol extract of sage.

[0063] The sage extract is dried sage, crushed, soaked in water at 60°C for 10 hours, filtered, refluxed with 8 times the weight of 70% ethanol solution and extracted 4 times, each time for 1 hour, and the combined filtrate was evaporated to dryness to obtain .

[0064]The preparation method of the above-mentioned radiation protection spray for external use on the skin is to weigh the sodium pyrrolidone carboxylate of the formulation amount and dissolve it in 80ml of purified water, a...

Embodiment 3

[0066] A kind of radiation protection spray for skin external use, described every 100 milliliters of skin radiation protection spray for external use is made up of following raw materials:

[0067] Trehalose 1g

[0068] Sodium alginate oligosaccharides 2g

[0069] Sage Extract 1g

[0070] Tea polyphenols 0.2g

[0071] L-Ascorbic acid 2-glucoside 0.2g

[0072] Sodium pyrrolidone carboxylate 1g

[0073] Purified water balance.

[0074] The sage extract is the ethanol extract of sage.

[0075] The sage extract is dried sage, crushed, soaked in water at 60°C for 8 hours, filtered, added 7 times the weight of 70% ethanol solution to reflux and extracted 3 times, each time for 2 hours, and the combined filtrate was evaporated to dryness to obtain .

[0076] The preparation method of the above-mentioned radiation protection spray for external use on the skin is to weigh the sodium pyrrolidone carboxylate of the formula and dissolve it in 70ml of purified water, and then add t...

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Abstract

The invention relates to the technical field of protection sprays and in particular relates to a skin external use type ray protection spray and a preparation method thereof. According to the skin external use type ray protection spray, trehalose, sodium alginate oligosaccharide, sage extract, tea polyphenol, L-ascorbic acid 2-glucoside and sodium pyrrolidonecarboxylate as raw materials; all the raw materials are mutually matched and can rapidly permeate into skin to clean free radicals, activate epidermal growth factors and repair damaged cell tissues; nutrient components are provided for damaged cells, the cell activity is enhanced and the self-resisting capability is improved; damages, caused by rays, to the skin are effectively reduced.

Description

technical field [0001] The invention relates to the technical field of protective sprays, in particular to a radiation protective spray for skin external use and a preparation method thereof. Background technique [0002] Radiation therapy is one of the three major treatment methods for cancer. It is a treatment method that irradiates tumors with rays of various energies to inhibit and kill cancer cells. However, due to the indirect effect of medical rays on the skin and mucous membrane tissue of the irradiated part during radiotherapy, that is, the medical ray ionizes the water molecules in the irradiated part of the tissue to generate a large number of toxic free radicals, which attack the irradiated part Tissue cells, and then cause radiation damage to the skin and mucous membrane tissue at the irradiated site. It has been reported that acute radiation skin and mucous membrane injury is an important factor affecting the effect of tumor treatment. For example, patients wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/12A61P17/16A61K31/353A61K31/4015A61K31/7016A61K31/7048A61K31/734
CPCA61K9/0014A61K9/12A61K31/353A61K31/4015A61K31/7016A61K31/7048A61K31/734A61K36/537A61K36/82A61K47/22A61P17/16A61K2300/00
Inventor 雷艳
Owner GUANGXI XINYE BIOLOGICAL TECH
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