The invention relates to middle and old-aged nourishing and wrinkle-resisting cream and a preparation method thereof. The middle and old-aged nourishing and wrinkle-resisting cream comprises phospholipids-coated nanometer anti-ageing repair active ingredients: nanometer coated supercritical extraction propolis, nanometer coated fresh royal jelly, nanometer coated beta hydroxy acid, nanometer coated ceramide, nanometer coated tocopheryl acetate, nanometer coated ascorbic acid 2-glucoside and nanometer coated MC-glucan; 2, natural functional emulsifiers and anti-oxidation skin-moistening grease: cetostearyl alcohol olive grease, sorbierite olive grease, cetostearyl alcohol-6 olive grease, kokum butter, wild peanut oil and wild camellia oil; and 3, natural functional preservatives: a honeysuckle flower extract and a natapres extract mixture. Compared with the prior art, the middle and old-aged nourishing and wrinkle-resisting cream has the advantages of no addition of preservatives, freeness from pigments, flavoring matters and mineral oil, safety, no irritation, high activity, quick percutaneous absorptivity, slow release, and capabilities of activating the growth of epidermal cells, prompting differentiation and proliferation of healthy cells, preserving moisture, resisting oxidation, repairing impaired skin cells, remarkably resisting wrinkles, and relaying ageing.