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Antiviral composition fermented by probiotics and its preparation method and application

A composition and technology of probiotics, applied in the field of medicine, can solve problems such as inability to detect quercetin metabolites

Active Publication Date: 2021-07-20
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, early studies by Dooth et al. (Dooth AN et al., J. Biol. Chem., 223:251, 1956) found that after oral administration of quercetin to mice, 3,4 - B-ring cleavage products such as dihydroxyphenylacetic acid, but these quercetin metabolites cannot be detected in urine if the animals are pre-administered with antibiotics (such as neomycin)

Method used

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  • Antiviral composition fermented by probiotics and its preparation method and application
  • Antiviral composition fermented by probiotics and its preparation method and application
  • Antiviral composition fermented by probiotics and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of fermented composition A

[0033] Weigh each traditional Chinese medicine ingredient according to the following weight: 20g of honeysuckle, 20g of Houttuynia cordata, 30g of poria cocos, 20g of dandelion, 15g of perilla leaf, 20g of rhizoma oleracea, 20g of purslane, 20g of sealwort, 20g of tangerine peel, 15g of gardenia, 15g of bellflower, licorice 5g;

[0034] Add the above herbs, soak in water, decoct for 1.0 hour, take the decoction, add water to decoct the dregs for 0.5 hour, combine the decoction, filter, and concentrate the filtrate to 950ml under reduced pressure (the relative density measured at 60°C is 1.02), add 7g glucose, 1g yeast powder, inorganic salt (FeSO 4 •7H 2 O 50mg, ZnSO 4 •7H 2 O 44mg, MgSO 4 •7H 2 O 0.3g, KH 2 PO 4 1.0g, K 2 HPO 4 •3H 2 (01.0g), 30g sucrose, 150mg sucralose, adjust the pH to 6.84, set the volume to 1000ml, and sterilize at 115°C for 40 minutes, when the temperature drops to 39°C, the v...

Embodiment 2

[0035] Embodiment 2: the preparation of fermentation composition B

[0036] Weigh each Chinese medicine ingredient according to the following weight: Bupleurum 60g, Honeysuckle 60g, Houttuynia cordata 60g, Scutellaria baicalensis 20g, Forsythia 60g, Radix isatidis 100g, Burdock seed 20g, Rhodiola rosea 20g, Nepeta 20g, Tangerine peel 20g, Licorice 20g;

[0037] Soak the above herbs in water, decoct for 1.5 hours, take the decoction, decoct the dregs with water for 1.0 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure until the relative density is 1.03 at 60°C, add 5g of glucose, 4g peptone, inorganic salts (FeSO 4 •7H 2 O 50mg, ZnSO 4 •7H 2 O 44mg, MgSO 4 •7H 2 O 0.3g, KH 2 PO 4 1.0g, K 2 HPO 4 •3H 2 O1.0g), 200mg of sucralose, adjust the pH to 7.20, set the volume to 1000ml, and sterilize at 121°C for 30 minutes, when the temperature drops to 30°C, the volume percentage of inoculation preculture is 0.5% Bacillus (CICC 21735),...

Embodiment 3

[0038] Embodiment 3: the preparation of fermentation composition C

[0039] Take each Chinese medicine composition by the following weight: honeysuckle 80g, Houttuynia cordata 80g, tangerine peel 48g, licorice 20g;

[0040] Soak the above herbs in water, decoct for 1.0 hour, take the decoction, add water to decoct the medicinal residues for 1.0 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure until the relative density is 1.02 at 60°C, add 10g of glucose, 2g yeast powder, 2g yeast extract, 5g peptone, inorganic salt (FeSO 4 •7H 2 O 10mg, ZnSO 4 •7H 2 O 44mg, MgSO 4 •7H 2 O 0.3mg, KH 2 PO 4 1.0g, K 2 HPO 4 •3H 2 O 1.0g), 100g sucrose, adjust the pH to 7.50, add water to make up to 1000ml, and sterilize at 110°C for 60 minutes, when the temperature drops to 37°C, the volume percentage of inoculation preculture is 1.0% respectively Bacteria of Bifidobacterium animalis (CICC6165), Bifidobacterium adolescentis (CICC 6176), Lactoba...

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Abstract

The invention discloses an antiviral composition fermented by probiotics and its preparation method and application. Nepeta, forsythia, poria cocos, dandelion, perilla leaves, fennel, sealwort, purslane, gardenia, bellflower soaked in water, decocted, concentrated, with or without adding carbon source, nitrogen source, inorganic salt, sweetness Agent, made by fermentation of probiotics. Tests have proved that the probiotic fermentation composition of the present invention has significant inhibitory effects on respiratory syncytial virus (RSV) Long strain, H1N1 influenza virus FM1 strain, and H1N1 Tamiflu-resistant strain in vitro; The inventive fermented composition has remarkable curative effect on influenza A H1N1 and is easy to accept by patients.

Description

technical field [0001] The invention relates to an antiviral composition fermented by probiotics and its preparation method and application, in particular to a composition for preventing and treating viral influenza, its preparation method and application, and belongs to the field of medical technology. Background technique [0002] Viral influenza is the most common infectious disease of the respiratory tract. Clinically, it is characterized by symptoms such as fever, chills, headache, nasal congestion, sneezing, runny nose, sore throat, cough, and hoarseness. The disease can come on in all seasons and at any age, and it can be transmitted by droplets containing virus, droplets, or contaminated utensils. Often when the body's resistance is reduced, such as being exposed to cold, fatigue, rain, etc., viruses and / or bacteria that already existed or invaded by the outside world will grow and reproduce rapidly and cause infection. Therefore how to cure viral influenza quickly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K36/752A61P31/14A61P31/16A61P11/00
CPCA61K36/076A61K36/185A61K36/195A61K36/233A61K36/28A61K36/288A61K36/315A61K36/346A61K36/355A61K36/41A61K36/484A61K36/53A61K36/535A61K36/538A61K36/539A61K36/634A61K36/744A61K36/752A61K36/78A61K36/8969A61K2236/19A61K2236/331A61K2236/39A61P11/00A61P31/14A61P31/16A61K2300/00
Inventor 吴炳新褚新红孙筱林吕美牛纪江
Owner SANZHU FUER PHARMA