Nano-Drug Delivery System Using Base as Carrier
A technology of nano-drugs and nano-assemblies, which is applied in the directions of drug delivery, drug combination, powder delivery, etc., can solve the problems of small application range, weak practicability, unsuitable for practical application, etc., and achieves improved drug loading and low toxicity. , the effect of structural stability
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[0055] The present invention also provides a preparation method of nanomedicine, including at least one of the following methods:
[0056] Method A: Put the drug and the carrier into the organic solvent in proportion, fully dissolve to obtain the first mixed solution, add the first mixed solution to ultrapure water or other solutions to obtain the second mixed solution, and remove the organic solvent in the second mixed solution to obtain Solutions of nanomedicines.
[0057] Method B: Put the drug and the carrier into the organic solvent in proportion, fully dissolve to obtain the first mixed solution, add ultrapure water or other solutions to the first mixed solution to obtain the second mixed solution, remove the organic solvent in the second mixed solution, Obtain the solution of nano drug;
[0058] Preferably, in method A and method B, the way of adding is dropwise.
[0059] Preferably, in method A, the step of removing the organic solvent includes: dialyzing the second ...
Embodiment 1
[0069] This embodiment provides a base-based drug delivery system, the preparation method of which comprises the following steps:
[0070] Take 42.2 mg of pemetrexed disodium and 25.6 mg of guanine ribonucleotide, put the two in a 20ml glass bottle, and add 0.5ml of dimethyl sulfoxide to dissolve the drug and the carrier, and the dissolution temperature is 25 °C, the dissolution time is 10 minutes, then add 5ml of ultrapure water, stir the whole system for 30 minutes, and then place the whole system in a dialysis bag with a molecular weight cut-off of 1000g / mol for dialysis for 4 hours to obtain an aqueous solution of nanomedicine.
[0071] Performance analysis and effect verification:
[0072] Such as figure 1 As shown, the morphology of the aqueous solution of the nano-drug shows a clear hollow vesicle-like structure under the transmission electron microscope, and the size of the vesicle formed by the self-assembly of the nano-drug is about 50nm to 100nm.
[0073] Such a...
Embodiment 2
[0078] This embodiment provides a base-based drug delivery system, the preparation method of which comprises the following steps:
[0079] Take 45.4 mg of the drug methotrexate and 28.3 mg of guanine deoxyribonucleotides, put the two in a 20ml glass bottle, and add 0.5ml of N,N'-dimethylformamide to dissolve the drug and the carrier, The dissolution temperature is 35°C, and the dissolution time is 5 minutes. After that, 5ml of PBS solution is added, and the whole system is stirred for 30 minutes. After that, the whole system is placed in a dialysis bag with a molecular weight cut-off of 1000g / mol and dialyzed for 4 hours to obtain nanomedicine. aqueous solution.
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