Method for preparing HA degradable coating on surface of magnesium alloy

A magnesium alloy and coating technology, which is applied in the field of biomedicine, can solve the problems of low cytocompatibility, HA coating easy to fall off, and implant failure, so as to improve antibacterial ability, good cytocompatibility, and reduce occurrence rate effect

Active Publication Date: 2018-10-23
XINXIANG UNIV
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Problems solved by technology

[0002] The bioceramic coating on the surface of magnesium alloy has been widely used as implant material because of its excellent biological properties. Currently, the commonly used material is hydroxyapatite, but due to its coating process and the stability of HA, the The

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[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0018] The present invention provides a technical solution: a method for preparing a HA degradable coating on the surface of a magnesium alloy. The specific steps of the method are as follows:

[0019] S1: The magnesium alloy surface is cleaned by ultrasonic vibration with 75% ethanol, followed by three times of three-distilled water ultrasonic vibration cleaning, drying, 600℃ radiation sterilization, and then placed for use. The ultrasonic vibration cleaning temperature is 50-60℃ , The working frequency of ultrasonic is be...

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Abstract

The invention discloses a method for preparing an HA degradable coating on the surface of magnesium alloy in the technical field of biological medicine. The method comprises the following concretely steps of S1, treating magnesium alloy base bodies; S2, preparing a sodium titanate solution; S3, preparing a transition layer on the magnesium alloy; S4, preparing nanometer antibacterial hydroxyapatite powder; S5, preparing a finished product. An HA coating grows on the surface of the magnesium alloy; the biological properties of the HA coating and the mechanical properties of the magnesium alloycan be simultaneously realized; the biological combination can be performed with bone tissues; nontoxicity is realized; harmful tissues cannot be generated; after being implemented into the human body, strong adhesion can be realized in a short time; the initial position fixation of implanting materials can be facilitated; in addition, antibacterial agents are added into the HA coating; the antibacterial cavity of the coating can be improved; the occurrence rate of the peri-implant inflammation can be reduced; the extensibility of the coating is good; good cellular morphology and proliferationrate are realized; good cell compatibility is realized.

Description

technical field [0001] The invention discloses a method for preparing a HA degradable coating on the surface of a magnesium alloy, specifically in the technical field of biomedicine. Background technique [0002] The bioceramic coating on the surface of magnesium alloy has been widely used as implant material because of its excellent biological properties. Currently, the commonly used material is hydroxyapatite, but due to its coating process and the stability of HA, the The HA coating dissolves rapidly in the body and leads to the failure of the implant. At the same time, the cytocompatibility between the HA coating and osteoblasts is not high, the HA coating is easy to fall off, and the stretchability on the surface of the material is poor. For this reason, we propose a method to prepare HA degradable coating on the surface of magnesium alloy and put it into use to solve the above problems. Contents of the invention [0003] The purpose of the present invention is to pr...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/32A61L27/54
CPCA61L27/047A61L27/32A61L27/54A61L2300/102A61L2300/104A61L2300/404A61L2300/606A61L2420/02A61L2430/02
Inventor 侯树森李伟莉贾焕丽曹鋆汇郝艺萌
Owner XINXIANG UNIV
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