Preparation and application of compound water adjuvant

A compound and water adjuvant technology, which is applied in the creation of new immune adjuvants for animal epidemics, and in the field of new compound water adjuvants, can solve the problems of compound adjuvants with complex components, large side effects, and inconsistent effects

Inactive Publication Date: 2018-10-26
CHINA AGRI VET BIO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, some compound adjuvants have complex components, the mechanism of action is not very clear, and the effects of different adjuvants on different antigen components are not consistent, and the side effects are relatively large.

Method used

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  • Preparation and application of compound water adjuvant
  • Preparation and application of compound water adjuvant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] 1. Determination and preparation of the formula of the foot-and-mouth disease compound water adjuvant vaccine

[0016] Through the orthogonal experiment design, three concentrations of Chinese medicine astragaloside, compound immunopotentiator, and immunostimulatory complex ISCOM were set respectively, and the proportion of high molecular polymer Carbomer 971 and water-based antigen was established. Three groups, respectively prepared foot-and-mouth disease compound water adjuvant vaccines were tested for physical properties, stability and other indicators, and the vaccine adjuvant formulas that met the quality standards were screened out.

[0017] 2. Quality evaluation of foot-and-mouth disease compound water adjuvant vaccine

[0018] (1) The prepared vaccine still maintains a clear, transparent and uniform appearance after centrifugation at 10,000 rpm for 20 minutes. No stratification is seen, and the color and clarity have no change, indicating that the vaccine has g...

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Abstract

The invention discloses a compound water adjuvant. The compound water adjuvant is composed of high molecular polymer, chemical compound immunopotentiator, traditional Chinese medicine immunopotentiator, biological immunopotentiator and water phase. The water adjuvant has the advantages that compared with a regular oil adjuvant, not only can humoral immunoresponse be stimulated, but also cell immunoresponse can be activated, granuloma at an injection position caused by viscous oil adjuvant vaccines is prevented, and the economic benefit of farmers is effectively improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to the creation of a novel compound water adjuvant for major animal epidemic diseases and a novel immune adjuvant for animal epidemic diseases. Background technique [0002] Traditional adjuvants are mostly mixed with antigens and injected into the body, which can easily cause side effects such as local inflammation, residual, and stress. Some new water-quality adjuvants discovered in recent years have enriched immune pathways and reduced local side effects. The development of adjuvants in the future provides new ideas, and the most popular adjuvants are composite and genotype adjuvants. The effect of using one adjuvant alone is sometimes very limited. In recent years, the use of different types of adjuvants together, or the use of some compound adjuvants with complex components has developed rapidly, such as traditional Chinese medicine compound adjuvant, Western medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61P37/04
CPCA61K39/39A61K2039/55511A61K2039/55577A61P37/04
Inventor 陈苗苗董金杰王凡张涛王会宝
Owner CHINA AGRI VET BIO SCI & TECH
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