A preparation process of spirulina protein and its neuroprotective application

A neuroprotective and spirulina technology, applied in the field of marine biology, can solve problems such as no reports on the application of spirulina protein, and achieve the effect of alleviating the toxicity of nerve damage
CN108752445BActive Publication Date: 2021-04-30GUANGDONG PHARMA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG PHARMA UNIV
Publication Date
2021-04-30

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Abstract

The invention belongs to the technical field of marine organisms, and relates to a preparation process of spirulina protein and its neuroprotective application. Specifically, the invention discloses a preparation method of spirulina protein. The spirulina powder is soaked, freeze-thawed, salted out, dialyzed and freeze-dried to obtain the spirulina protein. The spirulina protein provided by the present invention can reduce the survival rate of the nerve cell strain PC-12 under oxidative damage, reduce the aggregation of the toxic protein α-synuclein of the Parkinson's disease model nematode strain NL5901, and inhibit the Huntington's disease model Caenorhabditis elegans (AM141 ) can alleviate the neurotoxicity caused by Aβ toxic protein in the Alzheimer's disease model Caenorhabditis elegans (CL2355), and has neuroprotective function.
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Description

technical field

[0001] The invention belongs to the technical field of marine organisms, and in particular relates to a preparation process of spirulina protein and its neuroprotective application. Background technique

[0002] With the aging of the world population, there are more and more patients with neurodegenerative diseases closely related to aging. It is estimated that by 2050, the number of patients suffering from such diseases worldwide will reach 100 million. The pathogenesis and the search for effective prevention measures have become scientific research and social problems to be solved urgently.

[0003] The pathogenesis of neurodegenerative diseases is very complicated, but researchers believe that although neurodegenerative diseases have different causes and have their own characteristics in the early stages of the disease, there are many similarities between different diseases, especially in Asian countries. At the cellular level, abnormal protein aggregatio...

Claims

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