Intra-articular administration of polymetaphopsphates for the treatment of crystal arthropaties

A technology of polymetaphosphate and joint disease, applied in the field of polymetaphosphate, can solve the problems of difficult preparation of protein source and high production cost

Inactive Publication Date: 2018-11-23
OVER SRL +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these attempts have not yet found effective therapeutic applications, probably due to the difficulty in preparing sufficient protein-derived preparations due to antigenic issues and high production costs (Xu Y et al., Effects of pyrophosphate on dissolution of calcium pyrophosphate dihydrate crystals. J Rheumatol, 1991.18: 66-71; Shinozaki T et al., Calcium pyrophosphate dihydrate (CPPD) crystal dissolution by alkaline phosphatase: interaction of alkaline phosphate on CPPD crystals. J Rheumatol 1995,22:117-123)

Method used

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  • Intra-articular administration of polymetaphopsphates for the treatment of crystal arthropaties
  • Intra-articular administration of polymetaphopsphates for the treatment of crystal arthropaties
  • Intra-articular administration of polymetaphopsphates for the treatment of crystal arthropaties

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Embodiment Construction

[0027] Accordingly, the present invention provides, inter alia, a formulation for the treatment of arthropathy caused by microcrystalline deposition comprising a diluent aqueous sterile solution and formula M in the form of a sterile lyophilized powder n+2 P n o 3n The linear polymetaphosphate or formula (MPO 3 ) n cyclic polymetaphosphate, wherein M represents an alkali metal, wherein the volume of diluent solution is 100ml to 1500ml, and the weight / volume ratio of lyophilized polymetaphosphate powder to diluent solution is 1:1000 to 10:1000 , and wherein said treatment is based on reconstitution of polymetaphosphate powder in said diluent solution by

[0028] a) by stepwise lavage, i.e. by sequentially applying prescribed portions of said reconstitution solution to lavage the joint; or

[0029] b) Continuous lavage with the reconstituted solution.

[0030] The polymetaphosphate according to the invention is an alkali metal metaphosphate, preferably the sodium salt; more...

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Abstract

The invention relates to the use of polymetaphosphates for intra-articular application for the treatment of microcrystalline arthropathies. The preparation comprises a diluent water solution and a linear or cyclic polymetaphosphate in lyophilized powder, in which the volume of diluent solution and the weight / volume ratio of lyophilized polymetaphosphate powder and diluent solution are comprised within defined fields, and the treatment is carried out by step-wise lavage, i.e. using in succession a plurality of defined portions of reconstituted solution for a joint lavage, or by continuous lavage.

Description

technical field [0001] The present invention relates to the use of certain polymetaphosphate salts for intra-articular administration for the treatment of crystal arthropathy. More specifically, the present invention relates to continuous or stepwise joint lavage using formulations based on sodium polyphosphate of defined structure for the treatment of arthropathies caused by microcrystalline deposits originating from calcium deposits in joint tissue. Background technique [0002] It is well known that microcrystalline arthropathy is a group of inflammatory-degenerative disorders characterized by the deposition of minerals in the form of crystals in joints and periarticular structures. In particular, chondrocalcinosis, also known as pseudogout, is a disease characterized by microcrystalline deposits of calcium pyrophosphate dihydrate (CPPD), which has the chemical formula Ca 2 [O(PO 3 ) 2 ](2H 2 O), and has the following structure: [0003] [0004] Synovial seizures...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K9/00A61K9/14A61P19/02A61P19/06
CPCA61K9/0019A61K9/08A61K33/42A61K47/02A61P19/02A61K47/26
Inventor 纳塔尔·菲古拉乔瓦尼·卡瓦洛伊沃·潘泽里
Owner OVER SRL
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