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A kind of stable and long-acting compound diclazuril solution

A technology of diclazuril and solution, which is applied in medical formulations, active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, etc., can solve the problem of instability of diclazuril solution, inconvenient administration of mixing materials, and problems of drinking water. Problems such as organ blockage, to achieve the effect of short drug time, significant curative effect, and poor stability

Active Publication Date: 2021-03-26
山东牧邦动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The combination of diclazuril and hainanmycin sodium can achieve excellent effects of killing coccidiosis in different periods and stages. However, the two drugs have a great weakness that they are difficult to dissolve in water. If it is administered as a premix, it is very inconvenient due to the particularity of chicken feeding habits; if it is administered as a drinking water, because it is difficult to dissolve in water, it will cause problems such as blockage of drinking fountains.
In addition, diclazuril solution is unstable, making its use very limited

Method used

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  • A kind of stable and long-acting compound diclazuril solution
  • A kind of stable and long-acting compound diclazuril solution
  • A kind of stable and long-acting compound diclazuril solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The stable and long-acting compound diclazuril solution described in this embodiment adopts diclazuril, hainanmycin sodium, dehydrated alcohol, propylene glycol, polyvinylpyrrolidone K 30 , ethanolamine and OP-10; each 100L of the solution contains: 0.5kg of diclazuril, 0.5kg of hainanmycin sodium, 10kg of absolute ethanol, polyvinylpyrrolidone K 30 0.02kg, ethanolamine 0.02kg, OP-10 0.5kg, and the balance is propylene glycol.

[0022] Preferably, the absolute ethanol, propylene glycol, polyvinylpyrrolidone K30 and OP-10 are all pharmaceutical grades.

[0023] The preparation process of the stable long-acting compound diclazuril solution described in this embodiment comprises the following steps:

[0024] 1. Weigh 10 kg of absolute ethanol, add 0.5 kg of diclazuril and 0.5 kg of hainanmycin sodium, and stir well to obtain solution A;

[0025] 2. Weigh 0.02 kg of ethanolamine, add it into solution A prepared in step 1, stir until the solution is clear, and prepare sol...

Embodiment 2

[0031] The stable and long-acting compound diclazuril solution described in this embodiment adopts diclazuril, hainanmycin sodium, dehydrated alcohol, propylene glycol, polyvinylpyrrolidone K 30 , ethanolamine and OP-10; each 100L of the solution contains: 2.5kg of diclazuril, 2.5kg of hainanmycin sodium, 30kg of absolute ethanol, polyvinylpyrrolidone K 30 0.03kg, ethanolamine 0.03kg, OP-10 0.5kg, and the balance is propylene glycol.

[0032] Preferably, the absolute ethanol, propylene glycol, polyvinylpyrrolidone K30 and OP-10 are all pharmaceutical grades.

[0033] The preparation process of the stable long-acting compound diclazuril solution described in this embodiment comprises the following steps:

[0034] 1. Weigh 30kg of absolute ethanol, add 2.5kg of diclazuril and 2.5kg of hainanmycin sodium, and stir well to obtain solution A;

[0035] 2. Weigh 0.03 kg of ethanolamine, add it into solution A prepared in step 1, stir until the solution is clear, and prepare soluti...

Embodiment 3

[0041] The stable and long-acting compound diclazuril solution described in this embodiment adopts diclazuril, hainanmycin sodium, dehydrated alcohol, propylene glycol, polyvinylpyrrolidone K 30 , ethanolamine and OP-10; each 100L of the solution contains: 5kg of diclazuril, 5kg of hainanmycin sodium, 50kg of absolute ethanol, polyvinylpyrrolidone K 30 0.05kg, ethanolamine 0.05kg, OP-100.5kg, and the balance is propylene glycol.

[0042] Preferably, the absolute ethanol, propylene glycol, polyvinylpyrrolidone K30 and OP-10 are all pharmaceutical grades.

[0043] The preparation process of the stable long-acting compound diclazuril solution described in this embodiment comprises the following steps:

[0044] 1. Weigh 50 kg of absolute ethanol, add 5 kg of diclazuril and 5 kg of hainanmycin sodium, and stir evenly to obtain solution A;

[0045] 2. Weigh 0.05 kg of ethanolamine, add it to the solution A prepared in step 1, stir until the solution is clear, and prepare solution...

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Abstract

The invention relates to the technical field of veterinary preparation production, in particular to a stable and long-acting compound Diclazuril solution and a preparation technology thereof. The stable and long-acting compound Diclazuril solution is prepared from Diclazuril, HainanMycin sodium, anhydrous ethanol, propylene glycol, polyvinylpyrrolidone K30, ethanol amine and OP-10. According to the stable and long-acting compound Diclazuril solution, anhydrous ethanol is adopted as a solvent, ethanol amine serves as a cosolvent, OP-10 serves as an emulsifier, propylene glycol and polyvinylpyrrolidone K30 serve as a stabilizer, thus an uniform, stable and long-acting solution system is formed and applied to prevention and treatment of various coccidiosis of broilers, the bioavailability ofa solution preparation is improved, the problems of short drug acting time and poor stability are solved, and the stable and long-acting compound Diclazuril solution can also adapt to the habit of large-scale water drinking and drug using of poultry and is highly popular with farmers; and meanwhile, the preparation technology of the stable and long-acting compound Diclazuril solution is simple, low in cost and remarkable in curative effect, and the economic benefits of the farmers can be significantly improved.

Description

technical field [0001] The invention relates to the technical field of production of veterinary drug preparations, in particular to a stable and long-acting compound diclazuril solution. Background technique [0002] Chicken coccidiosis is an acute epidemic parasitic disease caused by one or more unicellular parasites of the genus Eimer. my country has listed it as a second-class animal disease. Among various chicken diseases, the incidence of coccidiosis is the highest, accounting for about 1 / 6-1 / 5, especially chicks within 3 months of age are the most susceptible to infection, and the mortality rate can reach 70%. It is not easy to recover health within a few months. The pathogen not only has a long survival period and strong resistance, it is difficult to be killed by general disinfection drugs, and the sick chicken may still have the pathogen excreted several months after the disease, thus prolonging the pollution cycle. Since the breeding conditions of large-scale an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/53A61K9/08A61K47/10A61K47/18A61K47/32A61P33/02
CPCA61K9/08A61K31/53A61K31/7048A61K47/10A61K47/18A61K47/32A61P33/02A61K2300/00
Inventor 郭怀龙孙远波孙远海李爽张传美
Owner 山东牧邦动物药业有限公司