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Application of sorafenib combined auranofin in preparation of medicine for treating liver cancer

A technology for treating liver cancer and inhibiting liver cancer, applied in the field of medicine, can solve the problems of low success rate, expensive and time-consuming new drug development and registration, and no auranofin liver cancer treatment, so as to improve the effect of inhibiting liver cancer

Inactive Publication Date: 2018-11-30
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Subsequent studies have found that auranofin has the potential to treat other diseases, but there is no report of auranofin for the treatment of liver cancer
[0006] The discovery, development and registration of new drugs in the clinic is an expensive and time-consuming process with a low success rate

Method used

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  • Application of sorafenib combined auranofin in preparation of medicine for treating liver cancer
  • Application of sorafenib combined auranofin in preparation of medicine for treating liver cancer
  • Application of sorafenib combined auranofin in preparation of medicine for treating liver cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, the combined drug regimen for the treatment of liver cancer

[0026] 1. Drug sensitivity

[0027] HepG2 and MHCC-97H liver cancer cells were inoculated in 96-well plates, and after adhering to the wall overnight, a series of drugs from high to low concentrations were prepared, and a control group was set up, with 3 replicate wells for each concentration. After incubation in the cell culture box for 48 hours, the proliferation of the cells was monitored with a cell dynamic detector (escolifesciences, CCL-170T-8), and the cell growth curve was drawn. The therapeutic concentrations of Sorafenib (Sora for short) and Auranofin (Aura for short) in HepG2 cells were: 5 μM and 0.4 μM respectively, and the therapeutic concentrations of Sorafenib and Auranofin in MHCC-97H cells were: 7 μM , 0.6μM (such as figure 1 Middle A-B).

[0028] 2. Cell growth curve

[0029] As we all know, auranofin is a thioredoxin reductase (TrxR) inhibitor, and TrxR belongs to the thio...

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Abstract

The invention relates to application of sorafenib combined auranofin in the preparation of a medicine for treating liver cancer. By combining auranofin and sorafenib, defects and insufficiencies of existing medicines and technologies for treating liver cancer are overcome, the curative effect of sorafenib on liver cancer can be remarkably raised, and a new means is provided for optimizing the treatment strategy of liver cancer in clinic. The product of the invention has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of sorafenib combined with auranofin in the preparation of drugs for treating liver cancer. Background technique [0002] According to the 2017 Chinese cancer statistics, the incidence of liver cancer ranks third in cancer incidence in my country, and the mortality rate ranks second in cancer deaths in my country. Hepatitis virus infection, nonalcoholic fatty liver disease, alcoholic liver disease, and aflatoxin are recognized high risk factors for liver cancer. Current treatment methods for liver cancer mainly include surgical resection, liver transplantation, local ablation, interventional therapy, radiotherapy, targeted therapy, and immunobiological therapy. The early diagnosis of liver cancer is difficult. Most patients are already in the advanced stage of liver cancer when they see a doctor, and they are not suitable for surgical treatment. Less...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7135A61K31/44A61P35/00A61P35/04
CPCA61K31/44A61K31/7135A61P35/00A61P35/04A61K2300/00
Inventor 唐霓汪凯张桂冀高庆祝郑亚秋
Owner CHONGQING MEDICAL UNIVERSITY