Blood cell pulse identification method and identification device based on the principle of sheath flow impedance

An identification method and blood cell technology, applied in the field of blood cell pulse identification method and identification device based on the principle of sheath flow impedance, can solve the problems of unguaranteed signal processing accuracy, low efficiency, and great influence on the results

Active Publication Date: 2020-12-25
MACCURA MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this method alleviates the influence of "M wave" to a certain extent, the efficiency of the entire statistical process is very low because of the need to extract data features and then screen abnormal pulses; in addition, in this method, the "M wave" and "m It is necessary to add a variety of experience-related thresholds when classifying waves, and the selection of thresholds has a great impact on the results, which makes it impossible to guarantee the accuracy of signal processing using this method

Method used

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  • Blood cell pulse identification method and identification device based on the principle of sheath flow impedance
  • Blood cell pulse identification method and identification device based on the principle of sheath flow impedance
  • Blood cell pulse identification method and identification device based on the principle of sheath flow impedance

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Embodiment 1

[0061] This embodiment is for the situation where the slope edge is the rising edge and the recognition direction of the pulse signal is the positive direction of the horizontal axis. Please refer to the attached Figure 1-3 to understand.

[0062] Please refer to image 3 , after acquiring a pulse signal, the blood cell pulse identification method sequentially performs the following steps:

[0063] S1) Find the rising edge of the pulse signal along the positive direction of the horizontal axis from the starting point;

[0064] S2) Find out the trough and the peak connected to the rising edge, and record the abscissa a corresponding to the trough, record the abscissa b corresponding to the peak, and record the relative height Δh of the pulse signal, where Δh=f(b)-f (a);

[0065] S3) find out the abscissa c corresponding to the end point of the pulse after crossing the crest in the positive direction along the abscissa axis, the height of the end point of the pulse is f(c), ...

Embodiment 2

[0087] This embodiment is for the situation where the slope edge is a falling edge and the recognition direction of the pulse signal is the negative direction of the horizontal axis. Please refer to the attached figure 1 , 2 and 4 for understanding.

[0088] Specifically, in the blood cell pulse recognition method disclosed in this embodiment, after a pulse signal is acquired, the blood cell pulse recognition method sequentially performs the following steps:

[0089] SI) Find the falling edge of the pulse signal from the starting point along the negative direction of the horizontal axis;

[0090] SII) Find out the trough and the peak connected to the falling edge, and record the abscissa a corresponding to the trough, and the abscissa b corresponding to the peak, and record the relative height Δh of the pulse signal, where , Δh=f(b)-f(a);

[0091] SⅢ) Find the abscissa c corresponding to the end point of the pulse after crossing the peak along the negative direction of the ...

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Abstract

The invention relates to a blood cell pulse identification method based on a focused flow impedance principle. The method includes 1) determining a gradient edge of a pulse signal; 2) finding out a wave trough and a wave peak, recording a horizontal coordinate a corresponding to the wave trough and a horizontal coordinate b corresponding to the wave peak, and recording a relative height [delta]hof the pulse signal, with the [delta]h being equal to f(a)-f(b); 3) finding out a horizontal coordinate c corresponding to a pulse end point, with the height of the pulse end point being f(c); 4) acquiring the number N of middle wave troughs between the wave peak and the pulse end point, if the N is 0, recording a second signal feature of the pulse signal, and if the N is not less than 1, enteringthe step 5); and 5) recording a middle wave trough closest to the wave peak in the horizontal axis positive direction as a start point, acquiring the horizontal coordinate d of the start point, recording a third signal feature of the pulse signal and returning to the step 1). The method is simple and rapid and a statistical result is more accurate and reliable. The invention also discloses a blood cell pulse identification device based on a focused flow impedance principle.

Description

technical field [0001] The invention relates to the technical field of detection, in particular to a blood cell pulse identification method and identification device based on the principle of sheath flow impedance used in the field of medical detection. Background technique [0002] At present, most blood cell analyzers use the Coulter principle to detect cells. The so-called Coulter principle specifically refers to the electrical impedance principle. This principle is to make cells suspended in electrolyte pass through a small hole, and an electrode is immersed on both sides of the small hole. , when cells pass through a small hole, the resistance changes to generate voltage pulses. The pulse amplitude is usually proportional to the volume of cell particles. These pulses can be used to measure the distribution and quantity of cell volume after amplification and identification. [0003] According to the above principles, only the amplitude of the pulse signal generated when ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/02G01N15/10
CPCG01N15/02G01N15/10G01N2015/0065G01N2015/1062
Inventor 周文静
Owner MACCURA MEDICAL INSTR CO LTD
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