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Method for preparing PEEK biological coating and PEEK biomaterial

A bio-coating and bio-material technology, applied in coatings, medical science, prostheses, etc., can solve problems such as easy peeling off, poor coating adhesion, and reduced mechanical properties of PEEK substrates

Inactive Publication Date: 2018-12-07
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, in these methods in the prior art, adding biologically active substances to the PEEK matrix will greatly reduce the mechanical properties of the PEEK matrix; and using plasma injection, magnetron sputtering surface modification method, because the bonding mode of the coating is Rely on physical bonding, so the prepared coating has poor bonding force and is prone to peeling off

Method used

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  • Method for preparing PEEK biological coating and PEEK biomaterial
  • Method for preparing PEEK biological coating and PEEK biomaterial
  • Method for preparing PEEK biological coating and PEEK biomaterial

Examples

Experimental program
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Effect test

Embodiment 1

[0068] A kind of PEEK biomaterial provided by the present embodiment comprises the following steps:

[0069] (1) Grind and polish PEEK first, then ultrasonically clean it with ethanol and deionized water three times respectively, and dry it at room temperature for later use.

[0070] (2) Prepare a mixed solution of 10 mmol / L Tris, and adjust the pH to 8.5 with hydrochloric acid. Dopamine was dissolved in the prepared Tris mixed solution, and a 2mg / ml dopamine solution was prepared for use.

[0071] (3) Put the PEEK prepared in step (1) into the dopamine solution prepared in step (2), and soak for 24 hours at room temperature under light-shielding conditions.

[0072] (4) Configure the concentration of 0.1mol / L (NH 4 ) 2 TiF 6 solution, the concentration is 0.3mol / L of H 3 BO 3 solution, the two were mixed in equal volumes, and the pH was adjusted to 2.7 with HF.

[0073] (5) PEEK prepared in step (3) was placed in the mixed solution prepared in step (4) and kept at 50° ...

Embodiment 2

[0075] A kind of PEEK biomaterial provided by the present embodiment comprises the following steps:

[0076] (1) Grind and polish PEEK first, then ultrasonically clean it with ethanol and deionized water three times respectively, and dry it at room temperature for later use.

[0077] (2) Configure a mixed solution of 10mmol / L Tris, and adjust the pH to 8.0 with hydrochloric acid. The dopamine was dissolved in the prepared Tris mixed solution, and a 1.5mg / ml dopamine solution was prepared for use.

[0078] (3) Put the PEEK prepared in step (1) into the dopamine solution prepared in step (2), and soak for 22 hours at room temperature under light-shielding conditions.

[0079] (4) The configuration concentration is 0.2mol / L (NH 4 ) 2 TiF 6 solution, the concentration is 0.4mol / L of H 3 BO 3 solution, the two were mixed in equal volumes, and the pH was adjusted to 2.9 with HF.

[0080] (5) PEEK prepared in step (3) was placed in the mixed solution prepared in step (4) and k...

Embodiment 3

[0082] A kind of PEEK biomaterial provided by the present embodiment comprises the following steps:

[0083] (1) Grind and polish PEEK first, then ultrasonically clean it with ethanol and deionized water three times respectively, and dry it at room temperature for later use.

[0084] (2) Configure a mixed solution of 10mmol / L Tris, and adjust the pH to 9.0 with hydrochloric acid. Dopamine was dissolved in the prepared Tris mixed solution, and a 2.5 mg / ml dopamine solution was prepared for use.

[0085] (3) Put the PEEK prepared in step (1) into the dopamine solution prepared in step (2), and soak for 25 hours at room temperature under light-shielding conditions.

[0086] (4) The configuration concentration is 0.16mol / L (NH 4 ) 2 TiF 6 solution, the concentration is 0.32mol / L of H 3 BO 3 solution, the two were mixed in equal volumes, and the pH was adjusted to 2.8 with HF.

[0087] (5) The PEEK prepared in step (3) was placed in the mixed solution prepared in step (4) an...

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Abstract

The invention relates to the field of biomaterials, and particularly relates to a method for preparing PEEK (Polyetheretherketone) biological coatings and a PEEK biomaterial. The PEEK, of which the surface is adhered with polydopamine, is put in a titanium fluoride solution; heat insulation is carried out for 10 hours to 15 hours at 45 DEG C to 55 DEG C and titanium fluoride is deposited; after the surface of the PEEK is adhered with the polydopamine, a titanium fluoride compounded coating is deposited; by using phenolic hydroxyl in the polydopamine as an anchoring point of titanium dioxide, the hybrid compounded coating is prepared through liquid phase deposition. Compared with the prior art, the compounded coating prepared by adopting the method disclosed by the invention has the advantages that the polydopamine and TiO2 are bonded through powerful chemical bonds, so that the bonding effect is very good. The titanium dioxide has an antibacterial effect, so that the finally prepared compounded coating has excellent antibacterial performance. Due to the polydopamine, adhesive growth of the fibroblasts can be promoted, and adhesion, growth and differentiation of the fibroblasts canbe effectively promoted; and finally, the sealing ability of soft tissues is achieved.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a method for preparing a PEEK biological coating and a PEEK biological material. Background technique [0002] PEEK Chinese name polyether ether ketone. It is a linear aromatic polymer compound containing chain links in the main molecular chain. Its constituent unit is oxygen-p-phenylene-oxygen-carbonyl-p-phenylene, which is a semi-crystalline and thermoplastic plastic. [0003] Polyetheretherketone (PEEK) resin is a special engineering plastic with excellent performance. Compared with other special engineering plastics, it has more significant advantages, such as high temperature resistance of 260 degrees, excellent mechanical properties, good self-lubrication, and chemical corrosion resistance. , flame retardant, peeling resistance, abrasion resistance, strong nitric acid, concentrated sulfuric acid, radiation resistance, super mechanical properties can be used in high-end...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/30A61L27/34A61L27/54
CPCA61L27/18A61L27/306A61L27/34A61L27/54A61L2300/102A61L2300/404A61L2420/02A61L2420/08C08L61/16C08L79/02
Inventor 万国江鲜鹏高帅张文泰唐帅钱军余莫小山黄楠
Owner SOUTHWEST JIAOTONG UNIV
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