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Optimal control method of nemadectin fermentation impurity

An optimized control and impurity technology, applied in the biological field, can solve the problem of high removal cost in the extraction section

Active Publication Date: 2018-12-11
NEW FOUNDER HLDG DEV LLC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing patent literature basically does not involve the optimal control method of the A1 impurity in the fermentation process of nimoctine, and the removal cost of this impurity is relatively high in the extraction process. Effective control in the fermentation process will undoubtedly greatly reduce the cost and increase the profit

Method used

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  • Optimal control method of nemadectin fermentation impurity
  • Optimal control method of nemadectin fermentation impurity
  • Optimal control method of nemadectin fermentation impurity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 150m 3 Fermentation tank process control:

[0047] Seed age: 66 hours

[0048] see figure 1 , the type of agitator in the fermenter: top four wide paddles 1+ middle four wide paddles 2+ bottom parabolic reverse installation (in the prior art, the protruding blades are opposite to the direction of rotation), the top agitator is about 4 on the stirring shaft 70% of the height; the four wide paddles 2 in the middle are located at 35% of the height, and the bottom is welded to install 8 stirring blades on the horizontal disc. figure 2 It is a schematic diagram of the installation of two parabolic blades 301 on a horizontal disc (other blades are not shown). The stirring paddle at the bottom of the agitator in the fermenter is a parabolic blade, and the parabolic convex part faces the direction of stirring, that is, the clockwise direction of the top view angle.

[0049] The parameters of the fermentation process are listed in Table 1.

[0050] Table 1: Example 1 ferme...

Embodiment 2

[0055] 150m 3 Fermentation tank process control:

[0056] Seed age: 65 hours.

[0057] Stirring type of fermenter: four wide paddles at the top + four wide paddles in the middle + parabolic reverse installation at the bottom. The parameters of the fermentation process are shown in Table 2.

[0058] Table 2: Example 2 fermentation parameters

[0059] peh h

Ventilation ratio vvm

Speed ​​rpm

Dissolved oxygen%

A1 impurity ratio%

after planting

1:0.25

30

100

10

1:0.60

40

66

16

1:0.60

80

48

22

1:0.70

100

46

31

1:0.70

90

60

46

1:0.70

90

68

70

1:0.70

90

76

94

1:0.70

90

81

2.6

142

1:0.49

56

79

2.0

166

1:0.49

56

84

2.2

190

1:0.49

56

86

1.9

262

1:0.37

39

76

1.8

286

1:0.37

39

77

1.6

310

1:0.37

39

75

1.5

...

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Abstract

The invention provides an optimal control method of a nemadectin fermentation impurity. The nimoktin fermentation impurity is of a structure before the moxidectin A impurity synthesis. The method comprises the operation steps of: controlling the age of seeds in a seed tank between 60 hours and 70 hours; reversely mounting bottom parabolic blades of the stirrer in a fermenting tank; and / or in the fermentation process, reducing the rotating speed of the stirrer in the fermenting tank after fermenting for 140 hours. The optimal control method of the nemadectin A1 fermentation impurity, which is provided by the invention, has the beneficial effects that the seed age control of the seed tank is refined and the control of the A1 impurity in the early stage after better viable seeds enter the fermenting tank is benefited; and through repeated observation and comparison, an optimized stirring pattern of the fermenting tank is screened out, the optimized stirring shearing force is small, the mixing is better, observed hyphae are more viable and the A1 impurity control in the early stage, of the fermenting tank, is benefited.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a method for fermenting and producing nimoctine. Background technique [0002] Nimoctine is a sixteen-membered macrolide antibiotic produced by Streptomycescyaneogriseussp.Noncyanogenus, which, like abamectin and milbemycin, exhibits good antiparasitic activity. Molecular weight: 612.8, chemical formula: C 36 h 52 o 8 . As an anti-parasitic antibiotic, Nimoctine has the advantages of wide insecticidal spectrum, easy degradation, low residue, no drug resistance, no harm to humans and animals, and less environmental pollution, and it can also be synthesized by Nimoctine. Moxidectin. [0003] The existing patent literature basically does not involve the optimal control method of the A1 impurity in the fermentation process of nimoctine, and the removal cost of this impurity is relatively high in the extraction process. Effective control in the fermentation process will u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q3/00C12P17/18C12M1/02C12M1/04
CPCC12M27/02C12M29/00C12P17/181C12Q3/00
Inventor 谭启茂杜森林张葵
Owner NEW FOUNDER HLDG DEV LLC
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