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A kind of compound low-concentration atropine drug eye drops and preparation method thereof

An eye drop, low-concentration technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of inconspicuousness and slow effect of myopia treatment, so as to reduce side effects, enhance the ability to resist visual fatigue and eye immunity , quick-acting effect

Active Publication Date: 2021-09-17
上海阿尔福斯医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although health care therapy has no side effects on the human body, the treatment effect on myopia is relatively slow or not obvious, and it needs to be used for a long time. For adolescents and children whose myopia grows rapidly and needs to be controlled and treated in time, a better treatment may be needed. choose

Method used

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  • A kind of compound low-concentration atropine drug eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Wash 50g of medlar and 25g of mint with distilled water, then put them into a decoction machine, add 300ml of water for injection equivalent to 4 times the mass of the solid, decoct with low heat for 0.5 hours, filter after cooling and add 5g of pearl liquid, accurately Measure this mixed solution volume and be 295ml; In the filtrate, add atropine sulfate 0.001% (w / v), lutein 0.001% (w / v), taurine 0.001% successively based on the content in eye drops (w / v), vitamin A 0.001% (w / v), vitamin B10.001% (w / v), vitamin B6 0.001% (w / v), vitamin B12 0.001% (w / v), vitamin E 0.001 % (w / v), borneol 0.001% (w / v), fully stirred, mixed evenly, according to the relevant requirements of "Chinese Pharmacopoeia 2015 Edition (four parts)" eye drops, adding sodium dihydrogen phosphate, adjusting the pH to 7.2, Add sodium chloride, adjust the osmotic pressure to 302mOsm / L, add sodium hyaluronate, adjust the viscosity to 8mps, mix evenly, filter through a 0.22μm microporous membrane, steriliz...

Embodiment 2

[0056]Wash 3000g of medlar and 100g of mint with distilled water, put them into a decoction machine, add 62000ml of water for injection equivalent to 20 times the mass of the solid, decoct with slow fire for 0.5 hours, filter after cooling and add 1500g of pearl liquid, accurately Measure this mixed solution volume and be 63430ml; In the filtrate, add tropicamide 0.1% (w / v), lutein 0.01% (w / v), taurine successively based on the content in the eye drops 0.1% (w / v), vitamin A 0.01% (w / v), vitamin B10.1% (w / v), vitamin B6 0.1% (w / v), vitamin B12 0.1% (w / v), vitamin E 0.1% (w / v), borneol 0.1% (w / v), fully stirred, mixed evenly, according to the relevant requirements of "Chinese Pharmacopoeia 2015 Edition (fourth)" eye drops, add borax, adjust the pH to 7.3, add Sodium chloride, adjust the osmotic pressure to 306mOsm / L, add methylcellulose, adjust the viscosity to 7mps, mix evenly, filter through a 0.22μm microporous membrane, sterilize, single-dose aseptic subpackaging, and pass t...

Embodiment 3

[0058] Wash 500g of medlar and 200g of mint with distilled water, then put them into a decoction machine, add 7000ml of water for injection equivalent to 10 times the mass of the solid, decoct with a slow fire for 3 hours, filter after cooling and add 100g of pearl liquid, accurately Measure this mixed solution volume and be 7030ml; In the filtrate, add atropine sulfate 1% (w / v), lutein 0.01% (w / v), taurine 1% successively based on the content in eye drops (w / v), Vitamin A 0.01% (w / v), Vitamin B1 1% (w / v), Vitamin B6 1% (w / v), Vitamin B12 1% (w / v), Vitamin E 1% (w / v), borneol 1% (w / v), fully stirred, mixed evenly, according to the relevant requirements of "Chinese Pharmacopoeia 2015 Edition (fourth)" eye drops, add sodium dihydrogen phosphate, adjust the pH to 7.4, add Sodium chloride, adjust the osmotic pressure to 302mOsm / L, add sodium hyaluronate, adjust the viscosity to 8mps, mix evenly, filter through a 0.22μm microporous membrane, sterilize, single-dose aseptic subpackag...

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Abstract

The invention discloses a compound low-concentration atropine drug eye drop and a preparation method thereof. The eye drops are mainly prepared from low-concentration atropine, lutein or lutein derivatives, wolfberry fruit, taurine, pearl liquid and various vitamins (A, B1, B6, B12, E) in a certain proportion. to make. The medicine used in the compound eye drops of the invention conforms to the Chinese Pharmacopoeia and the US Pharmacopoeia, utilizes the functional synergistic synergistic effect of various natural medicine active factors and atropine drugs on vision, effectively reduces the dosage of atropine drugs, and reduces the For human eye side effects, it can not only relieve ciliary muscle spasm, improve eyeball nutrition, but also effectively relieve visual fatigue, clear eyesight, clear heat and detoxify, and has the ability to enhance human eye immunity and anti-eye diseases, and effectively enhance the prevention and treatment of adolescents. The efficacy of children with myopia, at the same time, the eye drops have high safety performance, long shelf life, good biocompatibility with the eye environment, and have positive promotion and application value.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic medication of pharmaceutical preparations, and in particular relates to a compound low-concentration atropine drug eye drop and a preparation method thereof. Background technique [0002] As various electronic devices such as computers, mobile phones, and electronic game consoles enter society and families, these electronic devices have brought great convenience to people's work and study, but have also caused some impact on people's eyesight. Due to the long-term use of these electronic devices, the eyes are overused, and the vision continues to weaken after a long period of overloaded work. The main symptoms are: blurred vision, dry eyes, hyperemia, and photophobia, usually accompanied by systemic symptoms, such as Difficulty concentrating, listlessness, memory loss, insomnia, emotional irritability, etc., have greatly affected people's life and health. [0003] In recent years, due to the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61P27/10A61K9/08A61K47/46A61K47/10A61K47/22A61K47/20A61K31/46A61K31/4409A61K31/216A61K31/045A61K31/047A61K31/07A61K31/185A61K31/355A61K31/4415A61K31/51A61K31/714A61K35/618A61K36/534A61K36/815
CPCA61K9/0048A61K9/08A61K31/045A61K31/047A61K31/07A61K31/185A61K31/216A61K31/355A61K31/4409A61K31/4415A61K31/46A61K31/51A61K31/714A61K35/618A61K36/534A61K36/815A61K45/06A61K47/10A61K47/20A61K47/22A61K47/46A61P27/10A61K2300/00
Inventor 李大伟穆丹华周光大林建华张虹
Owner 上海阿尔福斯医药科技有限公司
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