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A self-healing injectable hydrogel dressing for diabetic wound repair and its preparation method and application

A technology for wound repair and water injection, which is applied in the field of biomedical materials and regenerative medicine, can solve the problems of easy infection of wounds, slow healing speed, and difficult vascularization, and achieve the effects of accelerating healing, easy access, and reducing residues.

Active Publication Date: 2021-06-11
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many hydrogel wound dressings in clinical practice, such as 3M Tegaderm, Kangweier, polyurethane gel, etc., they are relatively expensive and have not solved the key problems of easy infection of the wound, slow healing speed, and difficult vascularization.

Method used

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  • A self-healing injectable hydrogel dressing for diabetic wound repair and its preparation method and application
  • A self-healing injectable hydrogel dressing for diabetic wound repair and its preparation method and application
  • A self-healing injectable hydrogel dressing for diabetic wound repair and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 Preparation of hydrogel dressing

[0030](1) Preparation of alkylated pullulan (APu): Add 2 mmol of pullulan into 100 mL of deionized water, stir to dissolve completely; add 10 mmol of sodium periodate at a molar ratio of 1:5, The reaction was stirred and protected from light at room temperature for 5 hours. Then add ethylene glycol (molar ratio to sodium periodate: 2:1) to stop the reaction. After stirring for 1 hour, the reaction product was purified by 10,000 molecular weight dialysis bag for 3 days, and freeze-dried to obtain aldehydlated pullulan (APu);

[0031] (2) Preparation of F127-PEI polymer: Dissolve 0.5mmol F127 in 3.5mL dichloromethane, add 5mmol pyridine and 5mmol p-toluenesulfonyl chloride, react at room temperature for 24 hours, wash the reaction mixture with hydrochloric acid and saturated sodium bicarbonate, Precipitate with glacial ether, and the precipitated product is vacuum-dried to obtain F127-TsCl. Dissolve 0.25mmol F127-TsCl in 5...

Embodiment 2

[0034] The preparation of embodiment 2 hydrogel dressings

[0035] (1) Preparation of alkylated pullulan (APu): Add 2 mmol of pullulan into 100 mL of deionized water, stir to dissolve completely; add 10 mmol of sodium periodate at a molar ratio of 1:5, The reaction was stirred and protected from light at room temperature for 5 hours. Then add ethylene glycol (molar ratio to sodium periodate: 2:1) to stop the reaction. After stirring for 1 hour, the reaction product was purified by 10,000 molecular weight dialysis bag for 3 days, and freeze-dried to obtain aldehydlated pullulan (APu);

[0036] (2) Preparation of F127-PEI polymer: Dissolve 0.5mmol F127 in 3.5mL dichloromethane, add 5mmol pyridine and 5mmol p-toluenesulfonyl chloride, react at room temperature for 24 hours, wash the reaction mixture with hydrochloric acid and saturated sodium bicarbonate, Precipitate with glacial ether, and the precipitated product is vacuum-dried to obtain F127-TsCl. Dissolve 0.25mmol F127-TsC...

Embodiment 3

[0039] Example 3 Preparation of Hydrogel Dressing

[0040] (1) Preparation of alkylated pullulan (APu): Add 2 mmol of pullulan into 100 mL of deionized water, stir to dissolve completely; add 10 mmol of sodium periodate at a molar ratio of 1:5, The reaction was stirred and protected from light at room temperature for 5 hours. Then add ethylene glycol (molar ratio to sodium periodate: 2:1) to stop the reaction. After stirring for 1 hour, the reaction product was purified by 10,000 molecular weight dialysis bag for 3 days, and freeze-dried to obtain aldehydlated pullulan (APu);

[0041] (2) Preparation of F127-PEI polymer: Dissolve 0.5mmol F127 in 3.5mL dichloromethane, add 5mmol pyridine and 5mmol p-toluenesulfonyl chloride, react at room temperature for 24 hours, wash the reaction mixture with hydrochloric acid and saturated sodium bicarbonate, Precipitate with glacial ether, and the precipitated product is vacuum-dried to obtain F127-TsCl. Dissolve 0.25mmol F127-TsCl in 50m...

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Abstract

A self-healing injectable hydrogel dressing for diabetic wound repair and its preparation method and application. The preparation method of the invention is simple, has no organic solvent residue, mild reaction conditions, simple operation, and low raw material cost. At the same time, the experimental results show that the prepared self-healing injectable hydrogel dressing for diabetic wound repair has excellent temperature-sensitive, self-healing and injectable properties, and can significantly accelerate the healing of diabetic wounds.

Description

technical field [0001] The invention relates to the technical field of biomedical materials and regenerative medicine, in particular to a self-healing injectable hydrogel dressing for diabetic wound repair and its preparation method and application. Background technique [0002] Diabetic chronic wound is one of the common clinical diseases and the main cause of disability caused by diabetes. Due to metabolic disorders, impaired immune function and sluggish nerve response of diabetic patients, diabetic wounds are often difficult to heal on their own, and the course of the disease is long. , the occurrence and treatment of diabetic wounds is an increasingly serious social problem. For diabetic wounds, in addition to the general etiological treatment according to the patient’s condition, in view of the common surgical contraindications in diabetic patients, thorough and effective debridement of wounds, local topical drugs and dressings, etc. are very important treatment method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0057A61L26/0066A61L26/008A61L26/009A61L2300/30A61L2300/412A61L2300/604A61L2400/06C08L5/00C08L79/02C08L71/02
Inventor 毛葱雷波王敏徐天臻
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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