Curcumin wrapping method

A technology of curcumin and encapsulation, which is applied in the direction of medical formula, medical preparations of non-active ingredients, capsule delivery, etc., can solve the problem of lack of curcumin encapsulation materials, and achieve good biocompatibility, nano-dimensional stability, encapsulation The effect of simple process

Inactive Publication Date: 2019-01-04
HUIZHOU RES INST OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no nano-curcumin particles that can be stabilized in the water system for a long time in China, especially the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020] Example 1:

[0021] Add 252 mg mPEG- b -PCL, 31.5 mg Tween-80, 31.5 mg sodium lauryl amphoteric acetate and 105.7 mg curcumin were added to 10 mL of N,N-dimethylformamide, stirred at 25°C for 1 h, and placed in dialysis In a bag (Da 3500) and placed in the secondary water for 24 h dialyzing, the water is changed every 4 h. Then it is filtered, and the filtrate is freeze-dried for later use. The drug loading of curcumin by UV analysis was 15.1%. The particle size is 152.1 nm measured by a dynamic light scattering instrument.

Example Embodiment

[0022] Example 2:

[0023] Add 252 mg mPEG- b -PCL, 31.5 mg Tween-80, 31.5 mg sodium lauryl amphoteric acetate and 105.7 mg curcumin were added to 10 mL of N,N-dimethylformamide, stirred at 40°C for 1 h, and placed in dialysis In a bag (Da 3500) and placed in the secondary water for 12 h dialyzing, the water is changed every 4 h. Then it is filtered, and the filtrate is freeze-dried for later use. The drug loading of curcumin by UV analysis was 10.1%. The particle size is 132.1 nm measured by a dynamic light scattering instrument.

Example Embodiment

[0024] Example 3:

[0025] Add 252 mg mPEG- b -PCL, 31.5 mg Tween-80, 31.5 mg sodium lauryl amphoacetate and 105.7 mg curcumin were added to 10 mL of N,N-dimethylformamide, stirred at 50°C for 1 h, and placed in dialysis Put it in a bag (Da 3500) and place it in secondary water for dialysis for 48 h, changing the water every 4 h. Then it is filtered, and the filtrate is freeze-dried for later use. The drug loading of curcumin by UV analysis was 7.1%. The particle size is 114.1 nm measured by a dynamic light scattering instrument.

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PUM

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Abstract

The invention discloses a curcumin wrapping method. According to the curcumin wrapping method, an amphiphilic copolymer mPEG-b-PCL and an emulsifier are used as materials, and curcumin wrapping is achieved through the hydrophobic interaction. According to the curcumin wrapping method, a wrapping technology is simple and less organic solvent is needed. The emulsifier and the amphiphilic copolymer used in the curcumin wrapping method have good biocompatibility. The wrapped curcumin particles prepared according to the curcumin wrapping method provided by the invention have nanometer size and goodstability.

Description

technical field [0001] The invention relates to a wrapping technology of curcumin. Background technique [0002] Curcumin is a plant polyphenol extracted from turmeric rhizome and is the active ingredient in turmeric. Curcumin is one of the natural yellow pigments allowed to be used in food at home and abroad. It has stable color and low toxicity. It can be used as a colorant for some foods with strong coloring power. Curcumin has a good antioxidant effect and ability to scavenge free radicals. It is a natural antioxidant and is suitable for industries such as pharmaceuticals and cosmetics. Curcumin has the functions of preventing and inhibiting tumors, delaying senile dementia, lowering blood lipids and anti-inflammation, and preventing and alleviating diabetic complications. It has good clinical application value and research and development capabilities. Because curcumin has a wide range of biological activities and medicinal effects, it is often called "plant gold" b...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/34A61K47/26A61K47/12A61K31/12A61P39/06
CPCA61K9/5123A61K9/5146A61K31/12A61P39/06
Inventor 纪红兵林名钦
Owner HUIZHOU RES INST OF SUN YAT SEN UNIV
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