Preparation method for fenitrothion microcapsules

The technology of phosphalt and microcapsules is applied in the fields of botanical equipment and methods, insecticides, biocides, etc., and can solve the problems of complex process, high cost, environmental pollution, etc., and achieves environmental friendliness, less organic solvent, Simple preparation process

Inactive Publication Date: 2016-03-23
周德志
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since then, the research and development of microcapsules has carried out a lot of basic research in agriculture, and has made some progress. At present, more than 200 agrochemical companies are conducting research on the development and application of microcapsules. It has a history of more than 40 years, but compared with the field of pharmaceutical microcapsules, its development is relatively slow. At

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1

[0025] (1) Carrier preparation: Put the succinic acid, butanediol, lactic acid and 0.1wt% catalyst tetraisolactone titanium and phosphoric acid in a molar ratio of 1:1:0.2 into an electric booster stirrer and condense In a two-necked flask with a reflux tube, under the protection of nitrogen, the oil bath is heated to 240°C, dehydrated for 1h, and then evacuated, and the pressure is controlled until the vacuum degree is lower than 50Pa. The degreasing reaction is carried out, and the reaction is stopped after 3h. After cooling, the white solid polymer copolymer PBS-co-PLA is obtained, and the obtained product is vacuum dried at 60°C.

[0026] (2) Preparation of oil phase: accurately weigh 3.5mg PBS-co-PLA and dissolve it in 10mL dichloromethane. After it is completely dissolved, add 1mg of fenthion technical, stir well and accelerate the dissolution with an ultrasonic cleaner to obtain oil phase.

[0027] (3) Preparation of the water phase: Measure 98 mL of deion...

Example Embodiment

[0029] Example 2

[0030] (1) Carrier preparation: Put the succinic acid, butanediol, lactic acid and 0.12wt% of the catalyst tetraisolactone titanium and phosphoric acid in a molar ratio of 1:1:0.3 into an electric booster stirrer and condense In a two-necked flask with a reflux tube, under the protection of nitrogen, the oil bath is heated to 240℃, dehydrated for 1h, and then evacuated, the pressure is controlled until the vacuum degree is lower than 80Pa, the degreasing reaction is carried out, and the reaction is stopped after 4h. After cooling, the white solid polymer copolymer PBS-co-PLA is obtained, and the obtained product is vacuum dried at 60°C.

[0031] (2) Preparation of oil phase: accurately weigh 4.5mg PBS-co-PLA and dissolve it in 10mL dichloromethane. After it is completely dissolved, add 1mg of fenthion technical, stir well and accelerate the dissolution with an ultrasonic cleaner to obtain oil phase.

[0032] (3) Water phase preparation: Measure 98 mL of deionized...

Example Embodiment

[0034] Example 3

[0035] (1) Carrier preparation: Put the succinic acid, butanediol, lactic acid and 0.115wt% catalyst tetraisolactone titanium and phosphoric acid in a molar ratio of 1:1:0.25 into an electric booster stirrer and condense In a two-necked flask with a reflux tube, heated to 240°C in an oil bath under the protection of nitrogen, dehydrated for 1h, then evacuated, and controlled the pressure to a vacuum degree of less than 67Pa for degreasing reaction. The reaction was stopped after 3.5h. Under protection, after cooling, a white solid polymer copolymer PBS-co-PLA is obtained, and the resulting product is vacuum dried at 60°C.

[0036] (2) Preparation of the oil phase: accurately weigh 4mg PBS-co-PLA and dissolve it in 10 mL of dichloromethane. After it is completely dissolved, add 1mg of fenthion technical, stir well and accelerate the dissolution with an ultrasonic cleaner to obtain the oil phase .

[0037] (3) Preparation of water phase: Measure 98 mL of deionized ...

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Abstract

The invention relates to a preparation method for fenitrothion microcapsules. The preparation method comprises the following steps: firstly, carrier preparation is carried out, namely, a polymerization reaction with a mol ratio of succinic acid, butylene glycol and lactic acid being 1:1:0.2-0.3 is carried out, and a carrier PBS-co-PLA is obtained; secondly, oil phase preparation is carried out, namely, PBS-co-PLA, fenitrothion and dichloromethane are weighed with a mass ratio of PBS-co-PLA, fenitrothion and dichloromethane being 3.5-4.5:1:10, the PBS-co-PLA carrier is dissolved in dichloromethane, after the PBS-co-PLA is dissolved in dichloromethane fully, the fenitrothion active compound is added and dissolved and an oil phase is obtained; thirdly, water phase preparation is carried out, deionized water is measured and taken with a mass ratio of the oil phase to the water phase being 1:5-7, an emulsifier dispersant is added in water and dissolved and a water phase is obtained; fourthly, microcapsule preparation is carried out, namely, the oil phase is added in the water phase, an oil and water mixed emulsion is obtained, an antifoaming agent is added, microcapsule suspension is prepared after curing, water washing is carried out, the supernatant is removed, and a finished product is obtained after drying. The method is simple in technology and is environmentally friendly. The obtained fenitrothion microcapsules have a good form, the encapsulation efficiency is 78%, the drug loading capacity is 50%, the effective release period is 30 days, the drug release amount is 94%, and the fenitrothion microcapsule is an ideal pesticide sustained release agent.

Description

technical field [0001] The invention belongs to the technical field of pesticide preparation, and in particular relates to a preparation method of fenitrothion microcapsules. Background technique [0002] Fenitrothion (fenitrothion) is an organophosphorus insecticide. Moderate toxicity, low toxicity to humans and animals, the acute oral LD50 of rats is 400-800 mg / kg, and the acute percutaneous LD50 of rats is 1200 mg / kg. Fenitrothion has contact killing and stomach poisoning effects, no systemic and fumigation effects, medium residual effect period, wide insecticidal spectrum, special effect on Lepidoptera larvae, and can also control Hemiptera, Coleoptera and other pests. The drug is stable to light, and it is easy to decompose and fail when exposed to high temperature. It is hydrolyzed in alkaline medium, and iron, tin, aluminum, copper, etc. will cause the drug to decompose. It can be stored in glass bottles for a long time. [0003] Microcapsules (Microcapsules, MC) ar...

Claims

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Application Information

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IPC IPC(8): A01N57/14A01N25/28A01P7/04
CPCA01N57/14A01N25/28
Inventor 周德志
Owner 周德志
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