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A composition for treating oral ulcer and a preparation method thereof

A technology for oral ulcers and compositions, applied in the field of compositions for treating oral ulcers and their preparation, can solve the problems of ineffective drug concentration, inability to achieve rapid analgesia, short drug residence time, etc., and achieve isolation of external infection and accelerated healing Speed, easy-to-use effects

Inactive Publication Date: 2019-01-11
何凤姣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the special physiological environment of the oral cavity, most drugs stay in the oral cavity for a short time, which is difficult to adapt to the characteristics of the oral cavity, and cannot achieve a sustained effective drug concentration in the lesion; ordinary drugs dissolve quickly with the saliva after use, resulting in It is poor and needs to be used repeatedly, which will not only lead to the waste of the drug itself, but also cause adverse effects on the body when the drug enters the stomach with saliva; moreover, the drug effect of ordinary oral ulcer drugs is slow, and the pain is still unbearable after use, so it cannot achieve rapid recovery. analgesic effect

Method used

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  • A composition for treating oral ulcer and a preparation method thereof

Examples

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Embodiment 1

[0021] A composition for treating oral ulcers, comprising the following raw materials in parts by weight: 10 parts of tramadol, 10 parts of carotene, 12 parts of glucoside, 5 parts of hypericin, vitamin C3 4 parts, 4 parts of ropivacaine, 30 parts of film-forming aids, 4 parts of glucuronolactone, 8 parts of tributyl citrate, and 120 parts of distilled water.

[0022] Wherein, the film-forming aid is composed of propolis, sodium alginate and hydroxypropyl cellulose.

[0023] Wherein, the weight ratio of propolis, sodium alginate, and hydroxypropyl cellulose in the film-forming aid is 3:1:1.

[0024] In the present embodiment, the preparation method of the composition for the treatment of oral ulcers, the steps are as follows:

[0025] 1) Heating distilled water to 60°C, adding film-forming aids, stirring at 300r / min for 3min, cooling to 30°C to obtain a film-forming solution;

[0026] 2) Add tramadol, carotin, glucoside, hypericin, vitamin C, ropivacaine, glucuronolactone, t...

Embodiment 2

[0030] A composition for treating oral ulcers, comprising the following raw materials in parts by weight: 12 parts of tramadol, 11 parts of carotin, 14 parts of glucoside, 6 parts of hypericin, 4 parts of vitamin C, and 7 parts of ropivacaine , 45 parts of film-forming aids, 7 parts of glucuronolactone, 14 parts of tributyl citrate, and 140 parts of distilled water.

[0031] Wherein, the film-forming aid is composed of propolis, sodium alginate and hydroxypropyl cellulose.

[0032] Wherein, the weight ratio of propolis, sodium alginate, and hydroxypropyl cellulose in the film-forming aid is 3:1:1.

[0033] In the present embodiment, the preparation method of the composition for the treatment of oral ulcers, the steps are as follows:

[0034] 1) Heat the distilled water to 70°C, add film-forming aids, stir for 4 minutes at 400r / min, cool to 40°C, and obtain a film-forming solution;

[0035] 2) Add tramadol, carotin, glucoside, hypericin, vitamin C, ropivacaine, glucuronolacto...

Embodiment 3

[0039] A composition for treating oral ulcers, comprising the following raw materials in parts by weight: 15 parts of tramadol, 12 parts of carotin, 15 parts of glucoside, 8 parts of hypericin, 4.5 parts of vitamin C, and ropivacaine 6 parts, 40 parts of film-forming aids, 6 parts of glucuronolactone, 12 parts of tributyl citrate, and 135 parts of distilled water.

[0040] Wherein, the film-forming aid is composed of propolis, sodium alginate and hydroxypropyl cellulose.

[0041] Wherein, the weight ratio of propolis, sodium alginate, and hydroxypropyl cellulose in the film-forming aid is 3:1:1.

[0042] In the present embodiment, the preparation method of the composition for the treatment of oral ulcers, the steps are as follows:

[0043] 1) Heat the distilled water to 70°C, add film-forming aids, stir for 4 minutes at 400r / min, cool to 40°C, and obtain a film-forming solution;

[0044] 2) Add tramadol, carotin, glucoside, hypericin, vitamin C, ropivacaine, glucuronolactone...

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Abstract

The invention relates to the technical field of oral ulcer treatment, and discloses a composition for treating oral ulcer, comprising the following raw materials in parts by weight: tramadol 10-20 part, daucosterol 10-15 part, glucoside 12-18 part, hypericin 5-Ten, vitamin C3-Six, ropivacaine 4-8 part of film forming auxiliary agent 30-50 part of gluconolactone, 4-8 part, tributyl citrate 8-16 part, distilled wat 120-150 part. The invention also discloses a preparation method of the composition for treating oral ulcer. The composition for treating oral ulcer prepared by the invention can effectively treat oral ulcer and accelerate the healing speed of oral ulcer under the combined action of various raw materials; Through the addition of tramadol, can play an analgesic effect, effective speed, the effect is good.

Description

technical field [0001] The invention relates to the technical field of oral ulcer treatment, in particular to a composition for treating oral ulcer and a preparation method thereof. Background technique [0002] Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or poor keratosis. Tongue ulcers refer to oral ulcers that occur on the tongue and the abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. [0003] Due to the special physiological environment of the oral cavity, most drugs stay in the oral cavity for a short time, which is difficult to adapt to ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K31/137A61K31/225A61K31/375A61K31/445A61K31/704A61K31/7048A61P1/02
CPCA61K31/122A61K31/137A61K31/225A61K31/375A61K31/445A61K31/704A61K31/7048A61P1/02A61K2300/00
Inventor 何凤姣
Owner 何凤姣
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