Application of a class of alkaloids in reversing cisplatin resistance in lung cancer

An alkaloid and drug-resistant technology, applied in the field of medicine, can solve the problems of poor prognosis of patients, limited efficacy of combined chemotherapy, and survival rate of less than 15%.

Inactive Publication Date: 2019-01-15
普瑞赛森(山东)生物医学科技有限公司
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Problems solved by technology

NSCLC is prone to regional lymph node metastasis and hematogenous dissemination, and the prognosis of patients is poor, with a 5-year survival rate of less than 15%.
[0003] Cisplatin (DDP) is the first-line chemotherapy drug after lung cancer surgery, and natural and acquired drug resistance limit the efficacy of cisplatin-based combination chemotherapy

Method used

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  • Application of a class of alkaloids in reversing cisplatin resistance in lung cancer
  • Application of a class of alkaloids in reversing cisplatin resistance in lung cancer

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Embodiment Construction

[0024] The substantive content of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, but the protection scope of the present invention cannot be limited thereto.

[0025] 1. Experimental materials

[0026] The alkaloids studied and tested were prepared according to conventional methods and literature methods, and were divided into five categories according to their chemical structures. The specific chemical structures and numbers are shown in the table below.

[0027]

[0028] Lung cancer cell line H460 was purchased from ATCC, and DMEM medium and fetal bovine serum were purchased from GIBCO.

[0029] 2. Experimental method

[0030] 1. Cell culture

[0031] After routine resuscitation of human lung cancer cell line H460, use DMEM medium containing 10% FBS, 50U / ml streptomycin, 50U / ml penicillin and 4mmol / L L-glutamine at 37°C, 5% CO 2 Under the condition of cultivation, the medium was changed every 2-3 d...

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Abstract

The invention discloses an application of a class of alkaloids in reversing cisplatin resistance of lung cancer. Cisplatin (DDP) is the first-line chemotherapy drug after lung cancer surgery. The natural and acquired drug resistance limits the efficacy of cisplatin-based combination chemotherapy. Therefore, it is necessary to develop drugs to reverse cisplatin resistance of lung cancer. As found in that present invention, compounds TA-1, TA-2, TB-1, TB-2, TB-3, TC-1, TD-1, TE-1, and TE-2 can effectively reverse the resistance of lung cancer cells to cisplatin, in which TC-1, and TD-1 not onlycan reverse drug resistance, but also enhance the sensitivity of lung cancer cells to cisplatin. A compound TB-4 does not have this effect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of a class of alkaloids in reversing the drug resistance of lung cancer to cisplatin. Background technique [0002] Lung cancer is the most common malignant tumor of the respiratory system, and its morbidity and mortality rank first among malignant tumors, and it has an increasing trend year by year. From a clinical point of view, combined with the histological and biological characteristics of tumor cells, lung cancer is generally divided into two types: small cell lung cancer (SCLC) and non-small cell lung cancer (non-small celllung cancer, NSCLC). About 85% of lung cancers are NSCLC. NSCLC is prone to regional lymph node metastasis and hematogenous dissemination, and the prognosis of patients is poor, with a 5-year survival rate of less than 15%. [0003] Cisplatin (DDP) is the first-line chemotherapy drug after lung cancer surgery. Natural and acquired drug resistance l...

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Application Information

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IPC IPC(8): A61K31/439A61P35/00
CPCA61K31/439A61P35/00
Inventor 焦立英吕石翠王兆丽
Owner 普瑞赛森(山东)生物医学科技有限公司
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