A kind of polydithioacetal and its preparation method and application

A polydithioacetal and reaction technology, applied in the field of polymer materials, can solve problems such as limiting the effect of tumor treatment, affecting the survival and quality of life of patients, and achieving good biocompatibility, good degradability, and huge clinical applications. potential effect

Active Publication Date: 2021-07-20
SOUTH CHINA UNIV OF TECH
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  • Abstract
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  • Claims
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Problems solved by technology

[0002] During the course of chemotherapy, cancer cells will continue to evolve and produce multidrug resistance (MDR), which will seriously limit the effect of tumor treatment and affect the survival and quality of life of patients

Method used

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  • A kind of polydithioacetal and its preparation method and application
  • A kind of polydithioacetal and its preparation method and application
  • A kind of polydithioacetal and its preparation method and application

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Embodiment

[0050] A kind of polydithioacetal, its preparation method comprises the following steps (synthetic route figure is as follows figure 1 shown):

[0051] 1) 2.0g (15.13mmol) of cinnamaldehyde (CA), 3.21g (30.26mmol) of trimethyl orthoformate and 80mg (0.42mmol) of p-toluenesulfonic acid monohydrate were dispersed in 50mL of methanol, heated Reflux for 3h, then dilute the reaction solution with saturated sodium bicarbonate solution, then extract twice with ethyl acetate, collect the organic layer, wash with saturated sodium chloride solution for three times, collect the organic layer, dry with anhydrous magnesium sulfate, and then use The solvent is spin-dried by a rotary evaporator to obtain cinnamaldehyde methyl acetal (CA-acetal);

[0052] 2) Disperse 4.63g (30mmol) of 2-hydroxyethyl disulfide in 30mL of benzene, then disperse 10mg (0.05mmol) of p-toluenesulfonic acid monohydrate in 3.5mL of ethyl acetate, and then The two solutions were mixed, then 1.78g (10mmol) of cinnama...

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Abstract

The invention discloses a polydithioacetal and its preparation method and application. The polydithioacetal of the present invention has good biocompatibility and degradability, can self-assemble in the aqueous phase to form nanoparticles and be used as a transport carrier for hydrophobic anticancer drugs, and can be used in the acidity and degradability of lysosomes in tumor cells. In an environment with high glutathione content, hydrophobic anticancer drugs in the particle core can be rapidly released, amplifying the level of oxidative stress in tumor cells, thereby effectively reversing drug resistance, which has great potential for clinical application.

Description

technical field [0001] The invention relates to a polydithioacetal and its preparation method and application, belonging to the technical field of polymer materials. Background technique [0002] During the course of chemotherapy, cancer cells will continue to evolve and produce multidrug resistance (MDR), which will seriously limit the effect of tumor treatment and affect the survival and quality of life of patients. In the method of reversing multidrug resistance, regulating the level of reactive oxygen species (ROS) is a relatively effective method to kill multidrug-resistant cancer cells with diverse mechanisms. Reactive oxygen species in cancer cells play an important role in regulating and inducing apoptosis, and are closely related to the proliferation, survival and drug resistance of cancer cells. Compared with non-resistant cancer cells and normal cells, the ROS levels and antioxidant enzyme activities of drug-resistant cancer cells were significantly increased, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/73C08G18/66C08G18/32C08G18/48A61K9/51A61K47/34A61P35/00
CPCA61K9/5146A61K47/34A61P35/00C08G18/283C08G18/3863C08G18/73
Inventor 袁友永宗庆瑜王可伟肖炫姜茂麟李佶锶
Owner SOUTH CHINA UNIV OF TECH
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