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Analytical device and focusing method

A technology of analyzing device and optical axis direction, which is applied to analyzing materials, image analysis, measuring devices, etc., can solve the problems of low focusing accuracy, low contrast, discomfort, etc., and achieve the effect of high focusing accuracy.

Active Publication Date: 2021-07-20
ARKRAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the contrast method, there is a problem that the focus accuracy decreases when the contrast is low and the object is relatively small relative to the imaging range.
Sediment components in urine are small objects with low contrast with urine, so they are not suitable subjects for the contrast method

Method used

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  • Analytical device and focusing method

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Experimental program
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no. 1 approach

[0028] figure 1 It is a diagram showing a schematic configuration of the imaging device 1 of the first embodiment. The image pickup apparatus 1 is taken as a sample, for example, urine, and is used in an analytical apparatus for analyzing the photographed image. However, the image pickup apparatus 1 can also be used for analysis of the formation of a liquid samples other than urine such as cells, body fluids.

[0029] The imaging apparatus 1 has a camera 11, a light source 12, and a flow cell unit 13 for imaging a sample. The flow cell unit 13 has a stage 13b that is fixed to a flow cell 13a that is configured with a dosing body. The flow cell 13a can also be detached relative to the stage 13b. In addition, will figure 1 The length direction of the image pickup apparatus 1 is set to the X-axis direction in the orthogonal coordinate system, and the width direction is set to the Y-axis direction, and the height direction is set to the Z-axis direction. The sample flows in the Y-axi...

no. 2 approach

[0089]In the second embodiment, the coke point determination processing is different from the first embodiment. Other devices and controls are the same as those of the first embodiment, and thus the description thereof will be omitted. Here, the coke determination process according to the first embodiment is simple and the processing is simple and the calculation speed is rapid, but the robustness relative to the image with a low signal to noise ratio is low. Therefore, in the second embodiment, robustness is improved by comparing the inside and outside of the mask image.

[0090] Figure 11 It is a diagram for explaining the joint determination processing of the focus point. The formation of the mask image 32, the formation of the fuzzy image 33, the formation of the differential image 34 is the same as that of the first embodiment. In addition, the following will Figure 11 The range corresponding to the covered range (scope of the scope) in the mask image 32 is referred to as "m...

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Abstract

An analyzing device and a focusing method obtain an image of a formed component in a specimen with high focusing accuracy. The analysis device has: a flow cell having a flow path of a liquid containing a formed component; an imaging unit that photographs the liquid flowing in the flow path; The direction of the flow in the medium, adjust the relative position of the flow cell with respect to the imaging part; number to determine the camera position of the flow cell in at least one of the direction of the optical axis and the direction of liquid flow.

Description

Technical field [0001] The present invention relates to an analysis device and a focus alignment method. Background technique [0002] In the examination of the urine collected, it is known that the following method is known: one side performs shooting of the urine inspection in the flow cell, by analyzing the captured image (blood cell, epithelial cell) Analysis of tangible (solid) ingredients in urine such as cylindrical, bacteria, crystals (for example, refer to Patent Document 1). [0003] Patent Document 1: Japan Kaiping 10-104229 [0004] When the shaped ingredient in the sample flowing in the flow cell, it is considered that autofocus control is performed according to a contrast method as one of the focus method. However, in the contrast method, there is a problem: in the case where the contrast is low and the object is relatively small relative to the range of imaging, the focus accuracy is low. The sediment component in the urine is due to the low contrast with the urine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H04N5/232
CPCH04N23/67G01N2015/1452G01N2015/1413G01N15/1404G01N15/147G01N15/1484G01N15/1434G01N33/493H04N23/675H04N23/683G06T7/0016G06T2207/30024
Inventor 增田茂树中西健二
Owner ARKRAY INC
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