Surface plasma resonance imaging device and method

A surface plasmon and resonance imaging technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problem of small dynamic range of SPR imaging method, no cell adsorption force and cell stimulated response detection, SPR imaging method detection results and cells. The actual situation error and other problems can be reduced to reduce the inability to detect in time and reduce the error.

Active Publication Date: 2019-02-01
山东深大光学科技有限公司
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[0005] The main purpose of the present invention is to provide a surface plasmon resonance imaging device and method, aiming to solve the problem that the SPR imaging method in the prior art has a small dynamic range, and does not dete

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  • Surface plasma resonance imaging device and method

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[0018] In order to make the objectives, features, and advantages of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the description is The embodiments are only a part of the embodiments of the present invention, but not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work shall fall within the protection scope of the present invention.

[0019] See figure 1 , Is a surface plasmon resonance imaging device, including: a cell culture component 1, a first light source providing component 2, a light control component 3, and a resonance sensing component 4; the cell culture component 1 is used to receive cell growth and external stimulation The surface plasmon resonance sign...

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Abstract

The invention discloses a surface plasma resonance imaging device and a method, which are used for detecting the adsorption force and the stimulated response of cells, and solve the problem in the prior art that a large error exists between the detection result of the surface plasma resonance imaging method and the actual condition of cells. The device comprises: a cell culture assembly used for culturing cells and receiving surface plasma resonance signals generated in cell growth and external stimulation; a first light source providing member arranged on one side of the cell culture assemblyfor providing light stimulation to the cells; a light regulating assembly arranged between the cell culture assembly and the first light source providing member; and a resonance sensing assembly arranged on one side, far away from the light regulating assembly, of the cell culture assembly, which is used for acquiring a surface plasma resonance image according to the surface plasma resonance signals. According to the surface plasma resonance imaging device and the method, the error between the detection result of the surface plasma resonance imaging method and the actual condition of the cells is reduced.

Description

technical field [0001] The invention relates to the field of optical sensing imaging, in particular to a surface plasmon resonance imaging device and method. Background technique [0002] At present, the cellular mechanism of non-invasive phototherapy has not been fully understood, and there is an urgent need for highly sensitive online monitoring technology at the molecular level to interpret the cellular mechanism of non-invasive phototherapy. [0003] In the prior art, SPR (Surface Plasmon Resonance, Chinese name is Surface Plasmon Resonance) imaging method is usually used to detect cells, so as to interpret the cellular mechanism of non-invasive phototherapy according to the detection results. [0004] However, the SPR imaging methods in the prior art usually focus on the high-throughput biochemical reactions of cells as the main detection object, and do not detect the adsorption force of cells and the stimulated response of cells at the molecular level, resulting in the...

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Application Information

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IPC IPC(8): G01N21/552
CPCG01N21/554
Inventor 邵永红王雪亮曾佑君屈军乐
Owner 山东深大光学科技有限公司
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