Method for extracting artemisinin and purifying artemisinin by subcritical fluid technology

Abstract

The invention relates to a method for extracting artemisinin and purifying artemisinin by a subcritical fluid technology. The method comprises the following steps: smashing dried artemisia scoparia leaves, loading the smashed artemisia scoparia leaves into silk bags, putting the silk bags into an extraction tank, performing a preheating experiment and starting a vacuum pump; switching on a solventsampling valve of the extraction tank, injecting an organic solvent till all the silk bags are immersed by the solvent, switching on a hot water circulating system pump, and extracting to obtain an oil-soluble mixture; pressing the oil-soluble mixture into a separation tank from the extraction tank, heating, pressurizing and de-solventizing the oil-soluble mixture to obtain a liquid organic solvent and a liquid mixture; introducing the liquid organic solvent into a storage tank for recycling, and collecting an artemisinin crude product; dissolving the artemisinin crude extract in ethanol, fully dissolving, filtering, concentrating, cooling and crystallizing to obtain a crystal crude product; dissolving the crystal crude product in absolute ethyl alcohol, performing filtering after full dissolving, concentrating, cooling and crystallizing, drying in vacuum to obtain an artemisinin refined product. The method has the advantages of low energy consumption, and capability of realizing recycling of the organic solvent.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction technology, and in particular relates to a subcritical fluid technology for extracting artemisinin and a method for purifying artemisinin. Background technique [0002] Artemisia annua is a plant of the genus Artemisia in the family Asteraceae. "Prescription" records the method of treating malaria with Artemisia annua, "hold Artemisia annua, soak it in two liters of water, twist it to get the juice, and take it." It is also the earliest existing record of using Artemisia annua to treat malaria. Artemisia annua is divided into two types: Artemisia annua and Artemisia annua. Artemisia annua is an annual herb, and its medicinal part is the dry aerial part. It is cold in nature and bitter in taste, pungent, and returns to the liver and kidney meridians. It has antibacterial, antipyretic, cough and asthma properties. It can be used for fever due to summer heat, fever du...

AI Technical Summary

Problems solved by technology

[0005] At present, there are many studies on the extraction methods of artemisinin. According to the different purposes and scales, there are mainly industrial extraction and experimental extraction. Now the extraction methods of artemisinin mainly include organic solvent extraction, supercritical extraction and ultrasonic extraction. Among them, Organic solvent extraction is a widely used extraction method at present. According to the different organic solvents used, the extraction methods are different. The advantage of this method is that the solvents used are generally low in price, easy to obtain, and have low requirements for technical equipment. The main process of this type of method is: drying—crushing—soaking—extraction—concentrated extract—crude product—pure product—artemisinin. , chloroform, n-hexane and petroleum ether as solvents, petroleum ether is an ideal solvent, but this type of method requires multiple extractions of raw materials, a large demand for solvents, high energy consumption, long time, and consideration From the perspective of environmental protection and safety issues, the problem of this method has attracted more and more attention from enterprises.