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A light- and pH-responsive amphiphilic alginate and its stable pickering emulsion

A technology of emulsion and stabilizer, applied in the field of pickering emulsion, to achieve the effect of large preparation throughput, easy scale-up of production, and avoiding operation steps

Active Publication Date: 2021-08-03
HAINAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on the application of modified Alg to pickering emulsions

Method used

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  • A light- and pH-responsive amphiphilic alginate and its stable pickering emulsion
  • A light- and pH-responsive amphiphilic alginate and its stable pickering emulsion
  • A light- and pH-responsive amphiphilic alginate and its stable pickering emulsion

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Embodiment Construction

[0036] Referring to the accompanying drawings, the present invention will be further described in conjunction with specific embodiments, so as to better understand the present invention.

[0037] 1 Synthesis of host molecule Alg-β-CD

[0038] 1.1 Specific synthetic steps

[0039] Weigh 2.00 g of Alg into a round bottom flask, add 80 mL of distilled water, and dissolve it under mechanical stirring at room temperature for 6 h to obtain a homogeneous solution of sodium alginate (Alg) with a mass fraction of 2.5%, and adjust the solution with 0.5 mol / L HCl pH = 3.6, diluted with water to a mass fraction of 2%. Mono(6-amino-6-deoxy)-β-CD (1.37g, 1.3mmol), formaldehyde (1.8mmol) and cyclohexylisonitrile (1.8mmol) were successively added to the above sodium alginate solution, mechanically Stir and react at room temperature for 24h. After the reaction, the reaction solution was diluted with water to 0.7 wt%, and dialyzed for 3 days using a dialysis bag with a molecular weight cut o...

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Abstract

A light- and pH-responsive amphiphilic alginate and its stable pickering emulsion, the emulsion includes oil-water two-phase, and its stabilizer is nano-silica, main molecule alginate (Alg-β-CD) and the guest molecule Azo‑PEG, the volume ratio of the oil phase to the water phase is 1:0.1‑10, the concentration of silicon dioxide dispersed in the water phase is 2wt%; Alg‑β‑CD dispersed in the water phase The concentration of Azo‑PEG is 1g / L; the concentration of Azo‑PEG dispersed in the aqueous phase is 2g / L. The Pickering emulsion provided by the invention has strong stability, pH responsiveness and photoresponsiveness, and the controllable release of internal phase drugs can be realized by adjusting the pH or light. At the same time, the preparation method is simple in operation and has a large preparation flux. It is easier to realize the enlarged production of the emulsion, and has a wide range of applications and good promotion and application value in the fields of cosmetics, biology, pesticide drug delivery and the like.

Description

technical field [0001] The invention relates to a pickering emulsion, in particular to an amphiphilic alginate with light and pH response and its stable pickering emulsion. Background technique [0002] Pickering emulsion is a new type of emulsion system in which solid particles replace traditional surfactants. Such as figure 1 As shown, the stabilization mechanism of the emulsion is mainly through the adsorption of solid particles on the oil-water interface to form a single-layer or multi-layer structure of solid particles, thereby stabilizing the emulsion. [0003] Compared with emulsions stabilized by traditional surfactants, it has outstanding advantages: (1) less toxic and side effects on the human body; (2) reducing environmental pollution; (3) strong emulsion stability. Therefore, Pickering emulsion has very important research and application value in the fields of food, cosmetics and medicine. In recent decades, with the rapid development of modern technology, res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/03C08L71/02C08L5/04C08K3/36C08B37/04C08G65/337C08G65/333
CPCC08B37/0084C08G65/33396C08G65/337C08J3/03C08J2371/02C08J2405/04C08K3/36C08K2201/011
Inventor 李嘉诚冯玉红赵心宇余高波
Owner HAINAN UNIV
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