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Absorbable artificial cerebral dura mater and preparation method thereof

An artificial dura mater and one-sided technology, applied in the field of absorbable artificial dura mater and its preparation, can solve the problems of poor repair effect, unfavorable growth of brain tissue, and small aperture of artificial dura mater, so as to facilitate sticking and promote brain tissue growth , Improve the effect of the repair effect

Active Publication Date: 2019-02-22
南京普立蒙医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Purpose of the invention: In view of the problems that the existing artificial dura mater has a small aperture, is not conducive to the growth of brain tissue, and has poor repair effect, the present invention provides an absorbable artificial dura mater with a porous structure on one side and a dense structure on the other, and a Preparation method of artificial dura mater

Method used

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  • Absorbable artificial cerebral dura mater and preparation method thereof
  • Absorbable artificial cerebral dura mater and preparation method thereof
  • Absorbable artificial cerebral dura mater and preparation method thereof

Examples

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Effect test

Embodiment 1

[0022] Raw materials: hydrophilic biodegradable polymer material poly(lactide-glycolide)-polyethylene glycol-poly(lactide-glycolide) copolymer, hydrophobic biodegradable polymer material poly(lactide) ester-caprolactone).

[0023] The preparation method is: the poly(lactide-caprolactone) material is blown into a film to prepare a dense surface, and the poly(lactide-glycolide)-polyethylene glycol-poly(lactide-glycolide) ) The dioxane solution of the copolymer material is poured on the poly(lactide-caprolactone) material film, and the porous surface is obtained by freeze-drying. This film with different surface structures on both sides is the absorbable artificial hard film. meninges.

[0024] The SEM pictures of its porous surface and dense surface are as follows: Figure 1~2 , it can be seen that the porous surface has an obvious pore structure, and the pore size is 20-100 μm. After the cells were seeded on the porous surface of the absorbable artificial dura mater prepared...

Embodiment 2

[0026] Raw materials: hydrophilic biodegradable polymer material polylactide-polyethylene glycol-polylactide copolymer, hydrophobic biodegradable polymer material poly(lactide-glycolide).

[0027] Preparation method: The poly(lactide-glycolide) material is cast into a film to prepare a dense surface, and the dioxane solution of the poly(lactide-polyethylene glycol-polylactide copolymer material) is poured on the poly(acrylic acid) On the lactide-glycolide) membrane, the porous surface is obtained by freeze-drying, and the membrane with different surface structures on both sides is the absorbable artificial dura mater. The morphology and structural features of its porous surface and compact surface are similar to those in Example 1.

Embodiment 3

[0029] Raw materials: hydrophilic biodegradable polymer material polycaprolactone-polyethylene glycol-polycaprolactone copolymer, hydrophobic biodegradable polymer material poly(lactide-glycolide-caprolactone).

[0030] The preparation method is as follows: the poly(lactide-glycolide-caprolactone) material is extruded into a film to prepare a dense surface, and the poly(lactide-polyethylene glycol-polycaprolactone) copolymer material of dioxane The ring solution is poured on the poly(lactide-glycolide-caprolactone) material film, which is freeze-dried to obtain a porous surface. This film with different surface structures on both sides can absorb the artificial dura mater. The morphology and structural features of its porous surface and compact surface are similar to those in Example 1.

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Abstract

The invention provides an absorbable artificial cerebral dura mater and a preparation method thereof. According to the artificial cerebral dura mater, the surface, making contact with brain tissues, of the artificial cerebral dura mater is a porous structure surface formed by a hydrophilic biodegradable polymer material, and the surface, making contact with skulls, of the artificial cerebral duramater is a compact structure surface formed by a hydrophobic biodegradable polymer material. The preparation method comprises the following steps that firstly, the hydrophobic biodegradable polymer material is prepared into a compact structural membrane; a hydrophilic biodegradable polymer material solution is poured on one surface of the compact structural membrane, and freeze drying is carried out so as to obtain the porous structure surface. According to the absorbable artificial cerebral dura mater and the preparation method thereof, the size or morphology of pores of the porous structuresurface obtained through freeze drying can be regulated and controlled according to the freeze drying conditions, so that brain tissue cells can be conveniently fit and spread and can conveniently grow, and the repair effect can be improved; and the artificial cerebral dura mater is prepared by carrying out solution pouring and freeze drying on the compact membrane, the combination of the different structure surfaces is tighter, and the leakage of cerebrospinal fluid can be conveniently prevented.

Description

technical field [0001] The invention relates to an absorbable artificial dura mater and a preparation method thereof, belonging to the field of biological materials. Background technique [0002] The dura mater is a layer of connective tissue under the skull, which is used to protect the brain tissue. Craniotomy will lead to damage and loss of the dura mater. The defect of the dura mater will lead to the leakage of cerebrospinal fluid and easily lead to wound infection. Therefore, artificial dura mater is very important for the repair of dura mater after surgery. One side of the dura mater is in contact with the brain tissue, and the other is in contact with the skull. During the repair process, the side that contacts the brain tissue needs to be able to facilitate the adhesion, spreading and growth of cells to form new connective tissue, while the side that is in contact with the skull requires it to be dense, so that Prevent leakage of cerebrospinal fluid. The soft artif...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/56A61L27/58
CPCA61L27/18A61L27/56A61L27/58C08L67/04
Inventor 谢家银赵楠何斌蒲雨吉高陈承
Owner 南京普立蒙医疗科技有限公司
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