New-type nano ibuprofen tablet and preparation method thereof

A technology for ibuprofen tablets and tablets, which is applied in the directions of anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., can solve problems such as complicated preparation process, and achieve the effects of good water solubility, high drug dissolution, and low production cost.

Inactive Publication Date: 2019-03-01
安徽东盛友邦制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, reducing the particle size of drug particles can significantly improve its dissolution rate, thereby improving its bioavailability, but its preparation process is relatively complicated

Method used

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  • New-type nano ibuprofen tablet and preparation method thereof

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Effect test

Embodiment 1

[0016] Embodiment 1: A kind of novel nano ibuprofen tablet and preparation method thereof. The raw materials include the following components: ibuprofen, polyethylene glycol, starch, methylcellulose. The raw materials are weighed, and each component includes by weight: 15 parts of ibuprofen, 20 parts of polyethylene glycol, 30 parts of starch, and 10 parts of methylcellulose. Disperse p-ibuprofen in polyethylene glycol, spray dry, mix with starch and methyl cellulose, granulate, and then screen the materials taken out of the material boiling granulator. After adopting this embodiment, the content uniformity is good, the production cost is low, the preparation process is simple, the water solubility is good, the drug dissolution rate is high, and it can be absorbed orally, and can play analgesic, anti-inflammatory and antipyretic effects.

Embodiment 2

[0017] Embodiment 2: A kind of novel nano ibuprofen tablet and preparation method thereof. The raw materials include the following components: ibuprofen, polyethylene glycol, starch, methylcellulose. The raw materials are weighed, and each component includes by weight: 25 parts of ibuprofen, 30 parts of polyethylene glycol, 50 parts of starch, and 20 parts of methylcellulose. Disperse p-ibuprofen in polyethylene glycol, spray dry, mix with starch and methyl cellulose, granulate, and then screen the materials taken out of the material boiling granulator. After adopting this embodiment, the content uniformity is good, the production cost is low, the preparation process is simple, the water solubility is good, the drug dissolution rate is high, and it can be absorbed orally, and can play analgesic, anti-inflammatory and antipyretic effects.

Embodiment 3

[0018] Embodiment 3: A kind of novel nano ibuprofen tablet and preparation method thereof. The raw materials include the following components: ibuprofen, dispersant (one or more of ethanol, propylene glycol, dimethyl sulfoxide and polyvinylpyrrolidone), diluent (one or more of sucrose and dextrin) And binder (one or more of starch slurry, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose and ethyl cellulose). The raw materials are weighed, and each component includes: 15 parts of ibuprofen, 20 parts of dispersant, 30 parts of diluent, and 10 parts of adhesive in parts by weight. Disperse p-ibuprofen in one or more solutions of propylene glycol, polyethylene glycol, dimethyl sulfoxide and polyvinylpyrrolidone, spray dry it with one or more of sucrose and dextrin and starch pulp, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose and ethyl cellulose, granulated, and then the material is...

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Abstract

The invention relates to a new-type nano ibuprofen tablet and a preparation method thereof, and relates to the technical field of drugs. The tablet comprises the following components: ibuprofen, a dispersing agent, a diluent and a binding agent. A preparation process for the tablet comprises the following steps: firstly enabling the ibuprofen to be uniformly dispersed in the dispersing agent and forming nano sol, after spray-drying, mixing with the diluent and the binding agent, pelletizing, to obtain the nano ibuprofen tablet. The tablet can be rapidly dispersed in water, and a dissolution rate is apparently higher than that of a tablet prepared by mixing and pressing a crude drug and same auxiliary materials. The auxiliary materials related in the tablet are in comply with pharmacopeia standards, biodegradable and good in biocompatibility. The method is simple in process, safe in operation, low in cost, and easy to realize industrial production of a ibuprofen nano-drug.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a novel nano-ibuprofen tablet and a preparation method thereof. Background technique [0002] Ibuprofen has good analgesic and anti-inflammatory effects, and can treat various inflammations and other diseases. However, ibuprofen has poor water solubility and belongs to water-insoluble drugs. Therefore, its oral performance is poor, which makes its bioavailability low. [0003] In order to improve the solubility of ibuprofen in water, the research mainly focused on the difference of dosage form. Such as making spray (CN102204882A), clathrate (CN102258790A) and injection (CN1742714A) etc., the change of these formulations is not a permanent cure for the water solubility of ibuprofen, and there are problems such as high production cost and complex equipment. [0004] Improving the water solubility of ibuprofen is the key to improving its bioavailability. For poorly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/192A61P29/00
CPCA61K9/2054A61K9/2059A61K31/192A61P29/00
Inventor 傅兆瑞李广学苏悌胡丽芳卢强
Owner 安徽东盛友邦制药有限公司
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