A kind of method for producing high-purity phenolsulfonethylamide

Abstract

The invention discloses a method for producing high-purity etamsylate. The method comprises the following steps: carrying out a sulfonation reaction on hydroquinone serving as an initial material, a sulfonating agent, a dispersing agent and an organic solvent to obtain 2,5-dihydroxybenzenesulfonic acid; cooling the reaction solution to 45-70 DEG C, adding a mixed solution of diethylamine and waterto form a salt, cooling and crystallizing, so as to obtain the etamsylate. According to the reaction system used in the method, the fluidity of the system is improved, and the three-transfer-one-reaction efficiency is improved, so that the conversion rate of the materials is improved by 5-10%; when the system is cooled to 45-70 DEG C after the reaction is ended, the mixed solution of diethylamineand water is directly added into the system, the operation is simplified, and the after-treatment time is shortened; concentrated water is avoided, the energy consumption is reduced, and the yield ofthe product after salt formation reaches 80-85%; the product does not need to be re-crystallized or subjected to activated carbon discoloration, the purity directly reaches 99.5% or higher, and the content of all single impurities is lower than 0.05%; in addition, the use of a type of solvents and reagents containing genotoxicity warning structures is avoided, and totally safe and low-toxicity class-2 and class-3 solvents friendly to the humans and environment are used.

Description

technical field

[0001] The invention relates to the field of preparation of phensulfame, in particular to a method for producing high-purity phensulfame. Background technique

[0002] Etamsulfame, commonly known as hemostatic, is a synthetic hemostatic drug that can reduce capillary permeability, enhance capillary resistance, constrict blood vessels, shorten bleeding time, increase platelet circulation, increase platelet Aggregation and adhesion promote the release of coagulation active substances from platelets and accelerate the shrinkage of blood clots. It is a commonly used hemostatic drug in clinical practice. The hemostatic effect of Etsulfametamine is rapid and can last for 4 to 6 hours. It is suitable for the prevention and treatment of excessive surgical bleeding, thrombocytopenic purpura or allergic purpura and bleeding caused by other reasons, such as: cerebral hemorrhage, gastrointestinal bleeding, Urinary tract bleeding, fundus bleeding, gum bleeding, epistaxis...

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