Unlock instant, AI-driven research and patent intelligence for your innovation.
Systems and methods for automatically aligning, calibrating and normalizing electrophoretic data
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology using electrophoresis and standards, applied in chemical instruments and methods, chemical data visualization, separation methods, etc., can solve problems such as time-consuming and difficult electrophoresis data
Active Publication Date: 2021-06-01
AGILENT TECH INC
View PDF18 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
) However, even today, using electrophoretic data in analyte measurements is often difficult and time-consuming
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0107] Reference will now be made to various embodiments. While the invention will be described in conjunction with various embodiments, it will be understood that they are not intended to limit the invention to those embodiments. On the contrary, those skilled in the art can understand that the present invention is intended to cover various alternatives, modifications and equivalent embodiments.
[0108] According to various embodiments, figure 1 A block diagram of an exemplary data collection system is provided and shows a fluorescent polymer ladder 100, an unknown analyte mixture (sample) 101, and standards / controls used as markers or demarcations in the analysis usage of. In various embodiments, such analytes can have a suitable fluorescent dye tag attached to the analyte such that the fluorescent dye can be detected in the electrophoretic device or system. Any of various types of known electrophoretic devices may be used. In various embodiments, an electrophoretic dev...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The present invention provides a system and method for improving the analysis of analytes using an electrophoretic device. Exemplary methods of the invention may provide an increase in the yield of useful results (eg, quantity and quality of available data) in automated peak detection, eg, in combination with electrophoretic separations (eg, capillary electrophoresis). In various embodiments, the system virtualizes raw data, converting migration times into virtual units, thereby enabling visual comparison of analyte electropherograms and reliable measurement of unknown analytes. An analyte can be, for example, any organic or inorganic molecule, including, but not limited to, nucleic acids (DNA, RNA), proteins, peptides, glycans, metabolites, secondary metabolites, lipids, or any combination of the above. Analyte detection can be performed by any method including, but not limited to, fluorescence detection or UV absorption. Furthermore, the present invention provides consistent comparisons of sample-based, instrument-based, run-based, and migration time-based analyte peaks.
Description
technical field [0001] The present invention relates to an automated method for standardizing electrophoretic instruments to generate alignment data useful, for example, in analyte screening, research, qualitative or quantitative measurements, and diagnostic uses. Background technique [0002] For many years, capillary electrophoresis (CE) has been used as an analysis technique, for example, in the fields of life science, bioscience and pharmacy. (See, eg, YANXU, Chemistry Educator, Cleveland State University: Capillary Electrophoresis, New York: Springer Press, February 1996, Vol. 1, No. 1; which article is hereby incorporated by reference in its entirety .) However, even today, using electrophoretic data in analyte measurements is often difficult and time-consuming. In many cases, scientists and engineers must manually adjust raw electrophoretic data prior to peak integration and final detection of an analyte or mixture of analytes. A well-known challenge in this field i...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More